On the origin of leprosy

Marc Monot; Nadine Honoré; Thierry Garnier; Romulo Araoz; Jean Yves Coppée; Céline Lacroix; Samba Sow; John S. Spencer; Richard W. Truman; Diana L. Williams; Robert Gelber; Marcos Virmond; Béatrice Flageul; Sang Nae Cho; Baohong Ji; Alberto Paniz-Mondolfi; Jacinto Convit; Saroj Young; Paul E. Fine; Voahangy Rasolofo; Patrick J. Brennan; Stewart T. Cole

doi:10.1126/science/1109759

On the origin of leprosy

Marc Monot, Nadine Honoré, Thierry Garnier, Romulo Araoz, Jean Yves Coppée, Céline Lacroix, Samba Sow, John S. Spencer, Richard W. Truman, Diana L. Williams, Robert Gelber, Marcos Virmond, Béatrice Flageul, Sang Nae Cho, Baohong Ji, Alberto Paniz-Mondolfi, Jacinto Convit, Saroj Young, Paul E. Fine, Voahangy RasolofoPatrick J. Brennan, Stewart T. Cole

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

355 Citations (Scopus)

Abstract

Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

Original language	English
Pages (from-to)	1040-1042
Number of pages	3
Journal	Science
Volume	308
Issue number	5724
DOIs	https://doi.org/10.1126/science/1109759
Publication status	Published - 2005 May 13

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@article{03a63b83cda7429981cf195bc22bb35c,

title = "On the origin of leprosy",

abstract = "Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.",

author = "Marc Monot and Nadine Honor{\'e} and Thierry Garnier and Romulo Araoz and Copp{\'e}e, {Jean Yves} and C{\'e}line Lacroix and Samba Sow and Spencer, {John S.} and Truman, {Richard W.} and Williams, {Diana L.} and Robert Gelber and Marcos Virmond and B{\'e}atrice Flageul and Cho, {Sang Nae} and Baohong Ji and Alberto Paniz-Mondolfi and Jacinto Convit and Saroj Young and Fine, {Paul E.} and Voahangy Rasolofo and Brennan, {Patrick J.} and Cole, {Stewart T.}",

year = "2005",

month = may,

day = "13",

doi = "10.1126/science/1109759",

language = "English",

volume = "308",

pages = "1040--1042",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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Monot, M, Honoré, N, Garnier, T, Araoz, R, Coppée, JY, Lacroix, C, Sow, S, Spencer, JS, Truman, RW, Williams, DL, Gelber, R, Virmond, M, Flageul, B, Cho, SN, Ji, B, Paniz-Mondolfi, A, Convit, J, Young, S, Fine, PE, Rasolofo, V, Brennan, PJ & Cole, ST 2005, 'On the origin of leprosy', Science, vol. 308, no. 5724, pp. 1040-1042. https://doi.org/10.1126/science/1109759

TY - JOUR

T1 - On the origin of leprosy

AU - Monot, Marc

AU - Honoré, Nadine

AU - Garnier, Thierry

AU - Araoz, Romulo

AU - Coppée, Jean Yves

AU - Lacroix, Céline

AU - Sow, Samba

AU - Spencer, John S.

AU - Truman, Richard W.

AU - Williams, Diana L.

AU - Gelber, Robert

AU - Virmond, Marcos

AU - Flageul, Béatrice

AU - Cho, Sang Nae

AU - Ji, Baohong

AU - Paniz-Mondolfi, Alberto

AU - Convit, Jacinto

AU - Young, Saroj

AU - Fine, Paul E.

AU - Rasolofo, Voahangy

AU - Brennan, Patrick J.

AU - Cole, Stewart T.

PY - 2005/5/13

Y1 - 2005/5/13

N2 - Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

AB - Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.

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On the origin of leprosy

Abstract

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