Oleanane-type triterpene saponins from Aralia armata leaves and their cytotoxic activity

Pham Hai Yen; Nguyen Thị Hong Chuong; Giang Thi Kim Lien; Nguyen Thi Cuc; Nguyen Xuan Nhiem; Nguyen Thi Viet Thanh; Bui Huu Tai; Yohan Seo; Wan Namkung; Seon Ju Park; Seung Hyun Kim; Chau Van Minh; Phan Van Kiem

doi:10.1080/14786419.2020.1768090

Oleanane-type triterpene saponins from Aralia armata leaves and their cytotoxic activity

Pham Hai Yen, Nguyen Thị Hong Chuong, Giang Thi Kim Lien, Nguyen Thi Cuc, Nguyen Xuan Nhiem, Nguyen Thi Viet Thanh, Bui Huu Tai, Yohan Seo, Wan Namkung, Seon Ju Park, Seung Hyun Kim, Chau Van Minh, Phan Van Kiem

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Two new, aramatosides A and B (1 and 2), together with seven known oleanane-type triterpene saponins (3–9) were isolated from the leaves of Aralia armata. Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds 6–9 exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC₅₀ values ranging from 2.01 ± 0.17 to 18.8 ± 1.17 µM. Especially, compound 7 (narcissiflorin) showed significant cytotoxic activity against HT29 and A549 cell lines with IC₅₀ values of 2.02 ± 1.65 and 2.01 ± 0.17 µM, respectively, which are smaller than those of positive control irinotecan hydrochloride (IC₅₀ values of 10.3 ± 1.32 and 9.89 ± 0.19 µM).

Original language	English
Pages (from-to)	142-149
Number of pages	8
Journal	Natural Product Research
Volume	36
Issue number	1
DOIs	https://doi.org/10.1080/14786419.2020.1768090
Publication status	Published - 2022 Jan 1

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2017.08.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

UN SDGs

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title = "Oleanane-type triterpene saponins from Aralia armata leaves and their cytotoxic activity",

abstract = "Two new, aramatosides A and B (1 and 2), together with seven known oleanane-type triterpene saponins (3–9) were isolated from the leaves of Aralia armata. Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds 6–9 exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC50 values ranging from 2.01 ± 0.17 to 18.8 ± 1.17 µM. Especially, compound 7 (narcissiflorin) showed significant cytotoxic activity against HT29 and A549 cell lines with IC50 values of 2.02 ± 1.65 and 2.01 ± 0.17 µM, respectively, which are smaller than those of positive control irinotecan hydrochloride (IC50 values of 10.3 ± 1.32 and 9.89 ± 0.19 µM).",

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doi = "10.1080/14786419.2020.1768090",

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AU - Yen, Pham Hai

AU - Chuong, Nguyen Thị Hong

AU - Lien, Giang Thi Kim

AU - Cuc, Nguyen Thi

AU - Nhiem, Nguyen Xuan

AU - Thanh, Nguyen Thi Viet

AU - Tai, Bui Huu

AU - Seo, Yohan

AU - Namkung, Wan

AU - Park, Seon Ju

AU - Kim, Seung Hyun

AU - Minh, Chau Van

AU - Kiem, Phan Van

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2017.08. Publisher Copyright: © 2020 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Two new, aramatosides A and B (1 and 2), together with seven known oleanane-type triterpene saponins (3–9) were isolated from the leaves of Aralia armata. Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds 6–9 exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC50 values ranging from 2.01 ± 0.17 to 18.8 ± 1.17 µM. Especially, compound 7 (narcissiflorin) showed significant cytotoxic activity against HT29 and A549 cell lines with IC50 values of 2.02 ± 1.65 and 2.01 ± 0.17 µM, respectively, which are smaller than those of positive control irinotecan hydrochloride (IC50 values of 10.3 ± 1.32 and 9.89 ± 0.19 µM).

AB - Two new, aramatosides A and B (1 and 2), together with seven known oleanane-type triterpene saponins (3–9) were isolated from the leaves of Aralia armata. Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds 6–9 exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC50 values ranging from 2.01 ± 0.17 to 18.8 ± 1.17 µM. Especially, compound 7 (narcissiflorin) showed significant cytotoxic activity against HT29 and A549 cell lines with IC50 values of 2.02 ± 1.65 and 2.01 ± 0.17 µM, respectively, which are smaller than those of positive control irinotecan hydrochloride (IC50 values of 10.3 ± 1.32 and 9.89 ± 0.19 µM).

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Oleanane-type triterpene saponins from Aralia armata leaves and their cytotoxic activity

Abstract

Bibliographical note

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