Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities

Vu Kim Thu; Nguyen Van Thang; Nguyen Xuan Nhiem; Bui Huu Tai; Nguyen Hoai Nam; Phan Van Kiem; Chau Van Minh; Hoang Le Tuan Anh; Nanyoung Kim; Seonju Park; Seung Hyun Kim

doi:10.1016/j.phytochem.2015.05.001

Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities

Vu Kim Thu, Nguyen Van Thang, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Hoai Nam, Phan Van Kiem, Chau Van Minh, Hoang Le Tuan Anh, Nanyoung Kim, Seonju Park, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC₅₀ values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC₅₀ values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC₅₀ values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Phytochemistry
Volume	116
Issue number	1
DOIs	https://doi.org/10.1016/j.phytochem.2015.05.001
Publication status	Published - 2015

Bibliographical note

Funding Information:
This research was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.01-2012.24 and the Global Leading Technology Program of the Office of Strategic R&D Planning (OSP) funded by the Ministry of Knowledge Economy, Republic of Korea (No. 10039320 ).

Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytochem.2015.05.001

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title = "Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities",

abstract = "Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.",

author = "Thu, {Vu Kim} and {Van Thang}, Nguyen and Nhiem, {Nguyen Xuan} and Tai, {Bui Huu} and Nam, {Nguyen Hoai} and {Van Kiem}, Phan and {Van Minh}, Chau and {Le Tuan Anh}, Hoang and Nanyoung Kim and Seonju Park and Kim, {Seung Hyun}",

note = "Funding Information: This research was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.01-2012.24 and the Global Leading Technology Program of the Office of Strategic R&D Planning (OSP) funded by the Ministry of Knowledge Economy, Republic of Korea (No. 10039320 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",

year = "2015",

doi = "10.1016/j.phytochem.2015.05.001",

language = "English",

volume = "116",

pages = "213--220",

journal = "Phytochemistry",

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T1 - Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities

AU - Thu, Vu Kim

AU - Van Thang, Nguyen

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Nam, Nguyen Hoai

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Le Tuan Anh, Hoang

AU - Kim, Nanyoung

AU - Park, Seonju

AU - Kim, Seung Hyun

N1 - Funding Information: This research was supported by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under Grant number 104.01-2012.24 and the Global Leading Technology Program of the Office of Strategic R&D Planning (OSP) funded by the Ministry of Knowledge Economy, Republic of Korea (No. 10039320 ). Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.

AB - Eight oleanane-type saponins, glomerulosides A-H, were isolated from leaves of Glochidion glomerulatum. All isolated compounds were evaluated for cytotoxic activity on four human cancer cell lines, A-549, HT-29, OVCAR, and MCF-7. Glomerulosides C and E, which contain a benzoyloxy group at C-22, showed significant cytotoxic activities against the A-549, HT-29, and OVCAR cancer cell lines with IC50 values ranging from 5.9 to 9.8 μM. Glomeruloside A showed cytotoxicity on HT-29 and OVCAR cell lines with IC50 values of 7.3 and 6.6 μM, respectively. Moreover, glomeruloside B exhibited significant activity on A-549 and HT-29 cancer cell lines with IC50 values of 9.7 and 7.5 μM. In contrast, glomerulosides F-H, lacking a benzoyloxy group, showed only moderate cytotoxic activity.

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Oleanane-type saponins from Glochidion glomerulatum and their cytotoxic activities

Abstract

Bibliographical note

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UN SDGs

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