Off-Target                          18                         F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation

Jae Yong Choi; Hanna Cho; Sung Jun Ahn; Jae Hoon Lee; Young Hoon Ryu; Myung Sik Lee; Chul Hyoung Lyoo

doi:10.2967/jnumed.117.195248

Off-Target ¹⁸ F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation

Jae Yong Choi, Hanna Cho, Sung Jun Ahn, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyoo

Department of Neurology

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Off-target binding in the basal ganglia is commonly observed in the ¹⁸ F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R ₂ * MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent ¹⁸ F-AV-1451 PET and R ₂ * MRI studies. A correlation analysis was performed for age, ¹⁸ F-AV-1451 binding, and R ₂ * values. Results: There was an age-related increase in both ¹⁸ F-AV-1451 binding in the basal ganglia and R ₂ * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. ¹⁸ F-AV-1451 binding in the basal ganglia increased with R ₂ * values. Conclusion: Off-target ¹⁸ F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	Journal of Nuclear Medicine
Volume	59
Issue number	1
DOIs	https://doi.org/10.2967/jnumed.117.195248
Publication status	Published - 2018 Jan 1

Bibliographical note

Funding Information:
This study was financially supported by the “Mirae Medical” Faculty Research Assistance Program of Yonsei University College of Medicine (grant no. 6-2016-0162), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2015R1C1A2A01054507), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2017R1A2B2006694), and a Nuclear R&D Program of the National Research Foundation of Korea (no. NRF-2016M2A2A7024357). No other potential conflict of interest relevant to this article was reported.

Publisher Copyright:
COPYRIGHT © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

Access to Document

10.2967/jnumed.117.195248

Cite this

Choi, J. Y., Cho, H., Ahn, S. J., Lee, J. H., Ryu, Y. H., Lee, M. S., & Lyoo, C. H. (2018). Off-Target ¹⁸ F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation Journal of Nuclear Medicine, 59(1), 117-120. https://doi.org/10.2967/jnumed.117.195248

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title = " Off-Target 18 F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation ",

abstract = " Off-target binding in the basal ganglia is commonly observed in the 18 F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R 2 * MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18 F-AV-1451 PET and R 2 * MRI studies. A correlation analysis was performed for age, 18 F-AV-1451 binding, and R 2 * values. Results: There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. Conclusion: Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.",

author = "Choi, {Jae Yong} and Hanna Cho and Ahn, {Sung Jun} and Lee, {Jae Hoon} and Ryu, {Young Hoon} and Lee, {Myung Sik} and Lyoo, {Chul Hyoung}",

note = "Funding Information: This study was financially supported by the “Mirae Medical” Faculty Research Assistance Program of Yonsei University College of Medicine (grant no. 6-2016-0162), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2015R1C1A2A01054507), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2017R1A2B2006694), and a Nuclear R&D Program of the National Research Foundation of Korea (no. NRF-2016M2A2A7024357). No other potential conflict of interest relevant to this article was reported. Publisher Copyright: COPYRIGHT {\textcopyright} 2018 by the Society of Nuclear Medicine and Molecular Imaging.",

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Off-Target ¹⁸ F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation . / Choi, Jae Yong; Cho, Hanna; Ahn, Sung Jun et al.
In: Journal of Nuclear Medicine, Vol. 59, No. 1, 01.01.2018, p. 117-120.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Off-Target 18 F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation

AU - Choi, Jae Yong

AU - Cho, Hanna

AU - Ahn, Sung Jun

AU - Lee, Jae Hoon

AU - Ryu, Young Hoon

AU - Lee, Myung Sik

AU - Lyoo, Chul Hyoung

N1 - Funding Information: This study was financially supported by the “Mirae Medical” Faculty Research Assistance Program of Yonsei University College of Medicine (grant no. 6-2016-0162), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2015R1C1A2A01054507), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2017R1A2B2006694), and a Nuclear R&D Program of the National Research Foundation of Korea (no. NRF-2016M2A2A7024357). No other potential conflict of interest relevant to this article was reported. Publisher Copyright: COPYRIGHT © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Off-target binding in the basal ganglia is commonly observed in the 18 F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R 2 * MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18 F-AV-1451 PET and R 2 * MRI studies. A correlation analysis was performed for age, 18 F-AV-1451 binding, and R 2 * values. Results: There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. Conclusion: Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

AB - Off-target binding in the basal ganglia is commonly observed in the 18 F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R 2 * MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18 F-AV-1451 PET and R 2 * MRI studies. A correlation analysis was performed for age, 18 F-AV-1451 binding, and R 2 * values. Results: There was an age-related increase in both 18 F-AV-1451 binding in the basal ganglia and R 2 * values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18 F-AV-1451 binding in the basal ganglia increased with R 2 * values. Conclusion: Off-target 18 F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

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