Occupational exposure to crystalline silica and gastric cancer: A systematic review and meta-analysis

Wanhyung Lee, Yeon Soon Ahn, Seunghyun Lee, Bo Mi Song, Seri Hong, Jin Ha Yoon

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)


Crystalline silica is a widely used industrial material that is readily available worldwide, and is one of the most common types of particulate mineral pollutants. It has been classified as a group 1 human carcinogen of the respiratory system; however, whether it is linked to gastric cancer remains uncertain. We conducted a systemic review and meta-analyses to search for evidence of the relationship between gastric cancer and occupational exposure to crystalline silica. We searched for articles on occupations involving silica exposure and gastric cancer studies up to December 2014. Pooled-risk estimates of the association between occupational crystalline silica exposure and risk of gastric cancer were calculated by a random effects model. Metaregression analyses of industry type and histological confirmation status, study design and industrial subgroup analyses were performed. 29 articles, including 9 case-control and 20 cohort studies, were analysed. The overall summary effects size was 1.25 (95% CI 1.18 to 1.34) for the association of occupational silica exposure with gastric cancer. Both heterogeneity and publication bias were partially attenuated after subgroup analyses. Heterogeneity of studies was attenuated after metaregression by industry. Higher overall effects were observed in the mining and foundry industries. We found a significant relationship between occupational crystalline silica exposure and gastric cancer. Our results were strengthened by various subgroup analyses and, considering the biological plausibility of our premise, further studies are required to better understand this association.

Original languageEnglish
Pages (from-to)794-801
Number of pages8
JournalOccupational and Environmental Medicine
Issue number11
Publication statusPublished - 2016 Sept 12

Bibliographical note

Publisher Copyright:
© 2016 BMJ Publishing Group. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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