TY - JOUR
T1 - NT-proBNP
T2 - Is it a more significant risk factor for mortality than troponin T in incident hemodialysis Patients?
AU - Oh, Hyung Jung
AU - Lee, Mi Jung
AU - Lee, Hye Sun
AU - Park, Jung Tak
AU - Han, Seung Hyeok
AU - Yoo, Tae Hyun
AU - Kim, Yong Lim
AU - Kim, Yon Su
AU - Yang, Chul Woo
AU - Kim, Nam Ho
AU - Kang, Shin Wook
N1 - Publisher Copyright:
Copyright © 2014 Wolters Kluwer Health / Lippincott Williams & Wilkins.
PY - 2014/12/20
Y1 - 2014/12/20
N2 - Numerous studies have demonstrated that cardiac biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or measured 1 or 2 biomarkers. This study was to analyze the association between 3 cardiac biomarkers and mortality in incident HD patients. A prospective cohort of 864 incident HD patients was followed for 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patientswere divided into "high" and "low" groups, andCV and all-causemortalitywere compared between each group. Additionally, time-dependentROC curveswere constructed, and theNRI and IDI of the models with various biomarkers were calculated. The CV survival rates were significantly lower in the "high" NT-proBNP and cTnT groups compared to the corresponding "low" groups, while there was no significant difference in CV survival rate between the 2 hsCRP groups. However, all-cause mortality rates were significantly higher in all 3 "high" groups compared to each lower group. In multivariate analyses, only Ln NT-proBNP was found to be an independent predictor of mortality. Moreover, NT-proBNP was a more prognostic marker for mortality compared to cTnT. In conclusion, NT-proBNP is the biomarker that results in the most added prognostic value on top of traditional risk factors for CV and all-cause mortality in incident HD patients.
AB - Numerous studies have demonstrated that cardiac biomarkers are significant predictors of cardiovascular (CV) and all-cause mortality in ESRD patients, but most of the studies were retrospective or included small numbers of patients, only prevalent dialysis patients, or measured 1 or 2 biomarkers. This study was to analyze the association between 3 cardiac biomarkers and mortality in incident HD patients. A prospective cohort of 864 incident HD patients was followed for 30 months. Based on the median values of baseline NT-proBNP, cTnT, and hsCRP, the patientswere divided into "high" and "low" groups, andCV and all-causemortalitywere compared between each group. Additionally, time-dependentROC curveswere constructed, and theNRI and IDI of the models with various biomarkers were calculated. The CV survival rates were significantly lower in the "high" NT-proBNP and cTnT groups compared to the corresponding "low" groups, while there was no significant difference in CV survival rate between the 2 hsCRP groups. However, all-cause mortality rates were significantly higher in all 3 "high" groups compared to each lower group. In multivariate analyses, only Ln NT-proBNP was found to be an independent predictor of mortality. Moreover, NT-proBNP was a more prognostic marker for mortality compared to cTnT. In conclusion, NT-proBNP is the biomarker that results in the most added prognostic value on top of traditional risk factors for CV and all-cause mortality in incident HD patients.
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U2 - 10.1097/MD.0000000000000241
DO - 10.1097/MD.0000000000000241
M3 - Article
C2 - 25501091
AN - SCOPUS:84919383525
SN - 0025-7974
VL - 93
JO - Medicine (United States)
JF - Medicine (United States)
IS - 27
M1 - 241
ER -