NSCLC subtype prediction using cytologic fluid specimens from needle aspiration biopsies

Arthur Cho, Jin Hur, Yoo Jin Hong, Hye Jeong Lee, Young Jin Kim, Hee Yeong Kim, Ji Won Lee, Hyo Sup Shim, Byoung Wook Choi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


This study evaluated the diagnostic usefulness of tumor marker concentrations in cytologic fluids (CF) for subtyping non-small cell lung cancer (NSCLC) and assessed the relationship between fluorine-18- fluorodeoxyglucose (18F-FDG) uptake with serum and CF tumor marker levels. This prospective study included 88 patients diagnosed with adenocarcinoma or squamous cell carcinoma (SCC). Cytokeratin-19 fragment (CYFRA 21-1), carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) concentrations in the CF samples were correlated with serum tumor marker concentrations, 18F-FDG uptake, and NSCLC subtype. Fifty-eight patients were diagnosed with adenocarcinoma. Multivariate analysis revealed higher CF and serum SCCA levels; smoking status predicted SCC from adenocarcinoma. CF SCCA showed the highest accuracy (83%) in distinguishing between SCC and adenocarcinoma. CF samples obtained during routine needle aspiration biopsy procedure contain tumor marker levels sufficient to distinguish between SCC and adenocarcinoma; CF SCCA had the highest diagnostic accuracy.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalAmerican Journal of Clinical Pathology
Issue number3
Publication statusPublished - 2013 Mar

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


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