Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging

Sung Baek Seo; Jaemoon Yang; Woochan Hyung; Eun Jin Cho; Tong Il Lee; Yong Jin Song; Ho Geun Yoon; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1088/0957-4484/18/47/475105

Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging

Sung Baek Seo, Jaemoon Yang, Woochan Hyung, Eun Jin Cho, Tong Il Lee, Yong Jin Song, Ho Geun Yoon, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MPDCs consist of ultra-sensitive magnetic nanocrystals as MR probes and for magnetic targeting, and a chemotherapeutic agent encapsulated in poly(hexadecylcyanoacrylate) (PHDCA) nanoparticles. The PHDCA nanoparticles were further coated with polycationic polyethylenimine (PEI) to enhance cellular uptake efficiency. The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated. From the cell viability data, the MPDCs were nontoxic and the doxorubicin hydrochloride (DOX)-loaded MPDCs exhibited excellent tumorcidal efficacy.

Original language	English
Article number	475105
Journal	Nanotechnology
Volume	18
Issue number	47
DOIs	https://doi.org/10.1088/0957-4484/18/47/475105
Publication status	Published - 2007 Nov 28

All Science Journal Classification (ASJC) codes

Bioengineering
Chemistry(all)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/0957-4484/18/47/475105

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title = "Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging",

abstract = "Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MPDCs consist of ultra-sensitive magnetic nanocrystals as MR probes and for magnetic targeting, and a chemotherapeutic agent encapsulated in poly(hexadecylcyanoacrylate) (PHDCA) nanoparticles. The PHDCA nanoparticles were further coated with polycationic polyethylenimine (PEI) to enhance cellular uptake efficiency. The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated. From the cell viability data, the MPDCs were nontoxic and the doxorubicin hydrochloride (DOX)-loaded MPDCs exhibited excellent tumorcidal efficacy.",

author = "Seo, {Sung Baek} and Jaemoon Yang and Woochan Hyung and Cho, {Eun Jin} and Lee, {Tong Il} and Song, {Yong Jin} and Yoon, {Ho Geun} and Suh, {Jin Suck} and Huh, {Yong Min} and Seungjoo Haam",

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doi = "10.1088/0957-4484/18/47/475105",

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AU - Seo, Sung Baek

AU - Yang, Jaemoon

AU - Hyung, Woochan

AU - Cho, Eun Jin

AU - Lee, Tong Il

AU - Song, Yong Jin

AU - Yoon, Ho Geun

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

PY - 2007/11/28

Y1 - 2007/11/28

N2 - Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MPDCs consist of ultra-sensitive magnetic nanocrystals as MR probes and for magnetic targeting, and a chemotherapeutic agent encapsulated in poly(hexadecylcyanoacrylate) (PHDCA) nanoparticles. The PHDCA nanoparticles were further coated with polycationic polyethylenimine (PEI) to enhance cellular uptake efficiency. The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated. From the cell viability data, the MPDCs were nontoxic and the doxorubicin hydrochloride (DOX)-loaded MPDCs exhibited excellent tumorcidal efficacy.

AB - Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MPDCs consist of ultra-sensitive magnetic nanocrystals as MR probes and for magnetic targeting, and a chemotherapeutic agent encapsulated in poly(hexadecylcyanoacrylate) (PHDCA) nanoparticles. The PHDCA nanoparticles were further coated with polycationic polyethylenimine (PEI) to enhance cellular uptake efficiency. The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated. From the cell viability data, the MPDCs were nontoxic and the doxorubicin hydrochloride (DOX)-loaded MPDCs exhibited excellent tumorcidal efficacy.

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Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically targeted cancer therapy and diagnosis via magnetic resonance imaging

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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