Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Sujin Lee; Sony Marharjan; Jong Wha Jung; Nam Jung Kim; Kyeojin Kim; Young Taek Han; Changjin Lim; Hyun Jung Choi; Young Geun Kwon; Young Ger Suh

doi:10.1007/s12272-012-0308-3

Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Sujin Lee, Sony Marharjan, Jong Wha Jung, Nam Jung Kim, Kyeojin Kim, Young Taek Han, Changjin Lim, Hyun Jung Choi, Young Geun Kwon, Young Ger Suh

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

Original language	English
Pages (from-to)	455-460
Number of pages	6
Journal	Archives of pharmacal research
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s12272-012-0308-3
Publication status	Published - 2012 Mar

Bibliographical note

Funding Information:
This work is supported by a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea and the Research Institute of Pharmaceutical Science, Seoul National University.

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-012-0308-3

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title = "Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships",

abstract = "Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.",

author = "Sujin Lee and Sony Marharjan and Jung, {Jong Wha} and Kim, {Nam Jung} and Kyeojin Kim and Han, {Young Taek} and Changjin Lim and Choi, {Hyun Jung} and Kwon, {Young Geun} and Suh, {Young Ger}",

note = "Funding Information: This work is supported by a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea and the Research Institute of Pharmaceutical Science, Seoul National University.",

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doi = "10.1007/s12272-012-0308-3",

language = "English",

volume = "35",

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T1 - Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues

T2 - Insight into their structure-activity relationships

AU - Lee, Sujin

AU - Marharjan, Sony

AU - Jung, Jong Wha

AU - Kim, Nam Jung

AU - Kim, Kyeojin

AU - Han, Young Taek

AU - Lim, Changjin

AU - Choi, Hyun Jung

AU - Kwon, Young Geun

AU - Suh, Young Ger

N1 - Funding Information: This work is supported by a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea and the Research Institute of Pharmaceutical Science, Seoul National University.

PY - 2012/3

Y1 - 2012/3

N2 - Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

AB - Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.

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Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: Insight into their structure-activity relationships

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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