Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.
Bibliographical noteFunding Information:
This work is supported by a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea and the Research Institute of Pharmaceutical Science, Seoul National University.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery
- Organic Chemistry