Nonspecific interstitial pneumonitis after bortezomib and thalidomide treatment in a multiple myeloma patient

Wonseok Kang, Jin Seok Kim, Sang Ho Cho, Sung Kyu Kim, Joon Chang, Moo Suk Park

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Bortezomib, an inhibitor of 26S proteosome, is recently approved treatment option for multiple myeloma. Thalidomide, a drug with immunomodulating and antiangiogenic effects, has also shown promise as an effective treatment in multiple myeloma. Pulmonary complications are believed to be rare, especially interstitial lung disease. Here, we describe a patient with dyspnea and diffuse pulmonary infiltrates while receiving bortezomib and thalidomide in combination with dexamethasone for treatment-naïve multiple myeloma. Bronchoalveolar lavage demonstrated a significant decrease in the ratio of CD4: CD8 T lymphocytes (CD4/8 ratio, 0.54). Extensive workup for other causes, including infections, was negative. A lung biopsy under video-assisted thorascopic surgery revealed a diagnosis of nonspecific interstitial pneumonitis. The symptoms and imaging study findings improved after initiating steroid treatment. Physicians should be aware of this potential complication in patients receiving the novel molecular-targeted antineoplastic agents, bortezomib and thalidomide, who present with dyspnea and new pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalYonsei medical journal
Issue number3
Publication statusPublished - 2010 May

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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