TY - JOUR
T1 - Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing
AU - Kwon, Young Chang
AU - Baek, Seung Hee
AU - Lee, Hyangkyu
AU - Choe, Kwang Min
PY - 2010/3/19
Y1 - 2010/3/19
N2 - We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.
AB - We investigated cell shape changes during wound closure in the Drosophila larval epidermis. During reepithelialization, epidermal cells permanently change shape from pentagonal or hexagonal to irregular forms. This process requires zipper, a gene encoding the Drosophila nonmuscle myosin II heavy chain. Following wounding, myosin II is localized at the wound margin and at the rear end of individual cells located within several rows from the wound hole. The c-Jun N-terminal kinase (JNK) pathway is essential for this myosin II localization. These results suggest that not only the wound leading edge but also the cells lying distal to the leading edge cells actively participate in epithelial cell sheet migration during wound hole closure.
UR - http://www.scopus.com/inward/record.url?scp=77949490113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949490113&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2010.02.047
DO - 10.1016/j.bbrc.2010.02.047
M3 - Article
C2 - 20153725
AN - SCOPUS:77949490113
SN - 0006-291X
VL - 393
SP - 656
EP - 661
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -