Nonanal stimulates growth factors via cyclic adenosine monophosphate (Camp) signaling in human hair follicle dermal papilla cells

Soyoon Park, Wesuk Kang, Dabin Choi, Bomin Son, Taesun Park

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11 Citations (Scopus)


Human hair follicle dermal papilla cells (DPCs) are a specialized population of cells located in the hair follicles and regulate hair growth and development, particularly by releasing numerous growth factors in response to various physiological conditions. In the present study, we aimed to test whether nonanal, a scent compound from plants, stimulated growth factors in DPCs and to delineate the underlying mechanisms involved. We found that nonanal promoted DPC proliferation in a dose-dependent manner. Meanwhile, it also increased the intracellular cyclic adenosine monophosphate (cAMP) levels and the expression of various growth factor genes such as vascular endothelial growth factor, keratinocyte growth factor, and insulin-like growth factor 1. Furthermore, nonanal treatment stimulated DPC migration. Notably, the benefits of nonanal use were abrogated by cAMP inhibition. Our results reveal the potential of nonanal in preventing hair loss and suggest that its effects are cAMP-mediated in DPCs.

Original languageEnglish
Article number8054
Pages (from-to)1-13
Number of pages13
JournalInternational journal of molecular sciences
Issue number21
Publication statusPublished - 2020 Nov 1

Bibliographical note

Funding Information:
Funding: This work was supported by Innopolis Foundation through Technology Commercialization services(or Project), funded by Ministry of Science and ICT (2020-JB-RD-0080) and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2019R1A2C2003340).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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