Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

Jihyeon Lee; Won Seok Chang; Jaewoo Shin; Younghee Seo; Chanho Kong; Byeong Wook Song; Young Cheol Na; Bong Soo Kim; Jin Woo Chang

doi:10.1016/j.scr.2020.101726

Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

Jihyeon Lee, Won Seok Chang, Jaewoo Shin, Younghee Seo, Chanho Kong, Byeong Wook Song, Young Cheol Na, Bong Soo Kim, Jin Woo Chang

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.

Original language	English
Article number	101726
Journal	Stem Cell Research
Volume	43
DOIs	https://doi.org/10.1016/j.scr.2020.101726
Publication status	Published - 2020 Mar

Bibliographical note

Funding Information:
We would like to acknowledge Dong-Su Jang, MFA (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine) for his help with our illustrations.

Funding Information:
This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning, Republic of Korea (2016M3C7A1914123), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI19C1234) and a faculty research grant of Yonsei University College of Medicine, Republic of Korea (6–2018–0032).

Publisher Copyright:
© 2020

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

Access to Document

10.1016/j.scr.2020.101726

Cite this

@article{626c8201643348c2b19a0c0336fa309b,

title = "Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules",

abstract = "Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.",

author = "Jihyeon Lee and Chang, {Won Seok} and Jaewoo Shin and Younghee Seo and Chanho Kong and Song, {Byeong Wook} and Na, {Young Cheol} and Kim, {Bong Soo} and Chang, {Jin Woo}",

note = "Funding Information: We would like to acknowledge Dong-Su Jang, MFA (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine) for his help with our illustrations. Funding Information: This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning, Republic of Korea (2016M3C7A1914123), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI19C1234) and a faculty research grant of Yonsei University College of Medicine, Republic of Korea (6–2018–0032). Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = mar,

doi = "10.1016/j.scr.2020.101726",

language = "English",

volume = "43",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

TY - JOUR

T1 - Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

AU - Lee, Jihyeon

AU - Chang, Won Seok

AU - Shin, Jaewoo

AU - Seo, Younghee

AU - Kong, Chanho

AU - Song, Byeong Wook

AU - Na, Young Cheol

AU - Kim, Bong Soo

AU - Chang, Jin Woo

N1 - Funding Information: We would like to acknowledge Dong-Su Jang, MFA (Medical Illustrator, Medical Research Support Section, Yonsei University College of Medicine) for his help with our illustrations. Funding Information: This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning, Republic of Korea (2016M3C7A1914123), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI19C1234) and a faculty research grant of Yonsei University College of Medicine, Republic of Korea (6–2018–0032). Publisher Copyright: © 2020

PY - 2020/3

Y1 - 2020/3

N2 - Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.

AB - Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.

UR - http://www.scopus.com/inward/record.url?scp=85078745801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078745801&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2020.101726

DO - 10.1016/j.scr.2020.101726

M3 - Article

C2 - 32028085

AN - SCOPUS:85078745801

SN - 1873-5061

VL - 43

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 101726

ER -

Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this