Non-aqueous capillary electrophoretic separation and detection of 6H-pyrimido[2,1-a]isoindoles

Martin Pumera, Veronika Horká, Karel Nesměrák

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A non-aqueous capillary electrophoresis system for separating and detecting antidepressant drugs based on the coupling of capillary electrophoresis separation in acetonitrile and UV detection is described. The system offers a rapid simultaneous measurement in less than 12 min for six priority pyrimidoisoindoles. These antidepressants were detected down to the 2.5 × 10 -6-4.2 × 10 -6 mol/L level, with linearity up to the 1 × 10 -3 mol/L level examined. A highly stable response was observed for repetitive injections (R.S.D. < 2.6%, n = 12). The influence of pH and content of acetonitrile upon the electrophoretic mobilities was also studied.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalJournal of Separation Science
Issue number7
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Filtration and Separation


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