No Evidence of Reactivation of Hepatitis B Virus among Patients Treated with Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection

Mark S. Sulkowski; Wan Long Chuang; Jia Horng Kao; Jenny C. Yang; Bing Gao; Diana M. Brainard; Kwang Hyub Han; Edward Gane

doi:10.1093/cid/ciw507

No Evidence of Reactivation of Hepatitis B Virus among Patients Treated with Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection

Mark S. Sulkowski, Wan Long Chuang, Jia Horng Kao, Jenny C. Yang, Bing Gao, Diana M. Brainard, Kwang Hyub Han, Edward Gane

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir-sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed evidence of HBV reactivation.

Original language	English
Pages (from-to)	1202-1204
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	63
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciw507
Publication status	Published - 2016 Nov 1

Bibliographical note

Publisher Copyright:
© The Author 2016.

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

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10.1093/cid/ciw507

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title = "No Evidence of Reactivation of Hepatitis B Virus among Patients Treated with Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection",

abstract = "Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir-sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed evidence of HBV reactivation.",

author = "Sulkowski, {Mark S.} and Chuang, {Wan Long} and Kao, {Jia Horng} and Yang, {Jenny C.} and Bing Gao and Brainard, {Diana M.} and Han, {Kwang Hyub} and Edward Gane",

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AU - Sulkowski, Mark S.

AU - Chuang, Wan Long

AU - Kao, Jia Horng

AU - Yang, Jenny C.

AU - Gao, Bing

AU - Brainard, Diana M.

AU - Han, Kwang Hyub

AU - Gane, Edward

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N2 - Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir-sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed evidence of HBV reactivation.

AB - Postmarketing cases of hepatitis B virus (HBV) reactivation during hepatitis C treatment have been reported. We analyzed serum samples from patients in a clinical trial of ledipasvir-sofosbuvir in Taiwan and Korea. Of the 173 patients enrolled, 103 (60%) had been previously infected with HBV. None showed evidence of HBV reactivation.

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No Evidence of Reactivation of Hepatitis B Virus among Patients Treated with Ledipasvir-Sofosbuvir for Hepatitis C Virus Infection

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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