No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Hiromi Sawai, Nao Nishida, Hamdi Mbarek, Koichi Matsuda, Yoriko Mawatari, Megumi Yamaoka, Shuhei Hige, Jong Hon Kang, Koichi Abe, Satoshi Mochida, Masaaki Watanabe, Masayuki Kurosaki, Yasuhiro Asahina, Namiki Izumi, Masao Honda, Shuichi Kaneko, Eiji Tanaka, Kentaro Matsuura, Yoshito Itoh, Eiji MitaMasaaki Korenaga, Keisuke Hino, Yoshikazu Murawaki, Yoichi Hiasa, Tatsuya Ide, Kiyoaki Ito, Masaya Sugiyama, Sang H. Ahn, Kwang Hyub Han, Jun Y. Park, Man Fung Yuen, Yusuke Nakamura, Yasuhito Tanaka, Masashi Mizokami, Katsushi Tokunaga

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38 Citations (Scopus)


Background: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.Results: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.Conclusions: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.

Original languageEnglish
Article number47
JournalBMC Medical Genetics
Publication statusPublished - 2012 Jun 19

Bibliographical note

Funding Information:
This study was supported by a grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan (H23-kanen-005), and Japan Science and Technology Agency (09038024). We thank Dr. Minae Kawashima to giving us technical advices.

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)


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