New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities

Pham Thi Hong Minh, Do Tien Lam, Nguyen Quyet Tien, Nguyen Ngoc Tuan, Vu Phuong Nhung, Nong Van Hai, Phan Van Kiem, Nguyen Xuan Nhiem, Chau Van Minh, Park Seon Ju, Kim Seung Hyun

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2-5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines. Compound 3 exhibited moderate to weak cytotoxic activities on three human cancer cell lines, OVCAR, HT-29, and A-549, with IC50 values ranging from 16.2 to 36.4 μM.

Original languageEnglish
Pages (from-to)373-374
Number of pages2
JournalNatural product communications
Issue number3
Publication statusPublished - 2014 Mar

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


Dive into the research topics of 'New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities'. Together they form a unique fingerprint.

Cite this