TY - JOUR
T1 - New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities
AU - Minh, Pham Thi Hong
AU - Lam, Do Tien
AU - Tien, Nguyen Quyet
AU - Tuan, Nguyen Ngoc
AU - Nhung, Vu Phuong
AU - Hai, Nong Van
AU - Kiem, Phan Van
AU - Nhiem, Nguyen Xuan
AU - Minh, Chau Van
AU - Ju, Park Seon
AU - Hyun, Kim Seung
PY - 2014/3
Y1 - 2014/3
N2 - One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2-5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines. Compound 3 exhibited moderate to weak cytotoxic activities on three human cancer cell lines, OVCAR, HT-29, and A-549, with IC50 values ranging from 16.2 to 36.4 μM.
AB - One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2-5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines. Compound 3 exhibited moderate to weak cytotoxic activities on three human cancer cell lines, OVCAR, HT-29, and A-549, with IC50 values ranging from 16.2 to 36.4 μM.
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U2 - 10.1177/1934578x1400900324
DO - 10.1177/1934578x1400900324
M3 - Article
C2 - 24689220
AN - SCOPUS:84895458570
SN - 1934-578X
VL - 9
SP - 373
EP - 374
JO - Natural Product Communications
JF - Natural Product Communications
IS - 3
ER -
