New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society

Kazuo Tsubota; Norihiko Yokoi; Jun Shimazaki; Hitoshi Watanabe; Murat Dogru; Masakazu Yamada; Shigeru Kinoshita; Hyo Myung Kim; Hung Won Tchah; Joon Young Hyon; Kyung Chul Yoon; Kyoung Yul Seo; Xuguang Sun; Wei Chen; Lingyi Liang; Mingwu Li; Zuguo Liu; Yingping Deng; Jing Hong; Ying Jie; Ying Li; Hong Qi; Hua Wang; Xiaoming Yan; Wenzhao Yang; Yufeng Ye; Jin Yuan; Hong Zhang; Hui Zhan; Mingchang Zhang; Shaozhen Zhao; Chul Young Choi; Eui Sang Chung; Hyun Seung Kim; Mee Kum Kim; Myoung-Joon; Tae Im Kim; Do Hyung Lee; Hyung Keun Lee; Jong Suk Song; Shiro Amano; Reiko Arita; Yuichi Hori; Tetsuya Kawakita; Motoko Kawashima; Shizuka Koh; Kohji Nishida; Yoko Ogawa; Masahiko Yamaguchi

doi:10.1016/j.jtos.2016.09.003

New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society

Kazuo Tsubota, Norihiko Yokoi, Jun Shimazaki, Hitoshi Watanabe, Murat Dogru, Masakazu Yamada, Shigeru Kinoshita, Hyo Myung Kim, Hung Won Tchah, Joon Young Hyon, Kyung Chul Yoon, Kyoung Yul Seo, Xuguang Sun, Wei Chen, Lingyi Liang, Mingwu Li, Zuguo Liu, Yingping Deng, Jing Hong, Ying JieYing Li, Hong Qi, Hua Wang, Xiaoming Yan, Wenzhao Yang, Yufeng Ye, Jin Yuan, Hong Zhang, Hui Zhan, Mingchang Zhang, Shaozhen Zhao, Chul Young Choi, Eui Sang Chung, Hyun Seung Kim, Mee Kum Kim, Myoung-Joon, Tae Im Kim, Do Hyung Lee, Hyung Keun Lee, Jong Suk Song, Shiro Amano, Reiko Arita, Yuichi Hori, Tetsuya Kawakita, Motoko Kawashima, Shizuka Koh, Kohji Nishida, Yoko Ogawa, Masahiko Yamaguchi

Department of Ophthalmology

Research output: Contribution to journal › Review article › peer-review

360 Citations (Scopus)

Abstract

For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs other than short TFBUT. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: “Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage.” The definition stresses instability of the tear film as well as the importance of visual impairment, highlighting an essential role for TFBUT assessment. This paper discusses the concept of Tear Film Oriented Therapy (TFOT), which evolved from the definition of dry eye, emphasizing the importance of a stable tear film.

Original language	English
Pages (from-to)	65-76
Number of pages	12
Journal	Ocular Surface
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.jtos.2016.09.003
Publication status	Published - 2017 Jan 1

Bibliographical note

Publisher Copyright:
© 2016 The Author(s)

All Science Journal Classification (ASJC) codes

Ophthalmology

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10.1016/j.jtos.2016.09.003

Cite this

Tsubota, K., Yokoi, N., Shimazaki, J., Watanabe, H., Dogru, M., Yamada, M., Kinoshita, S., Kim, H. M., Tchah, H. W., Hyon, J. Y., Yoon, K. C., Seo, K. Y., Sun, X., Chen, W., Liang, L., Li, M., Liu, Z., Deng, Y., Hong, J., ... Yamaguchi, M. (2017). New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society. Ocular Surface, 15(1), 65-76. https://doi.org/10.1016/j.jtos.2016.09.003

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title = "New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society",

abstract = "For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs other than short TFBUT. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: “Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage.” The definition stresses instability of the tear film as well as the importance of visual impairment, highlighting an essential role for TFBUT assessment. This paper discusses the concept of Tear Film Oriented Therapy (TFOT), which evolved from the definition of dry eye, emphasizing the importance of a stable tear film.",

author = "Kazuo Tsubota and Norihiko Yokoi and Jun Shimazaki and Hitoshi Watanabe and Murat Dogru and Masakazu Yamada and Shigeru Kinoshita and Kim, {Hyo Myung} and Tchah, {Hung Won} and Hyon, {Joon Young} and Yoon, {Kyung Chul} and Seo, {Kyoung Yul} and Xuguang Sun and Wei Chen and Lingyi Liang and Mingwu Li and Zuguo Liu and Yingping Deng and Jing Hong and Ying Jie and Ying Li and Hong Qi and Hua Wang and Xiaoming Yan and Wenzhao Yang and Yufeng Ye and Jin Yuan and Hong Zhang and Hui Zhan and Mingchang Zhang and Shaozhen Zhao and Choi, {Chul Young} and Chung, {Eui Sang} and Kim, {Hyun Seung} and Kim, {Mee Kum} and Myoung-Joon and Kim, {Tae Im} and Lee, {Do Hyung} and Lee, {Hyung Keun} and Song, {Jong Suk} and Shiro Amano and Reiko Arita and Yuichi Hori and Tetsuya Kawakita and Motoko Kawashima and Shizuka Koh and Kohji Nishida and Yoko Ogawa and Masahiko Yamaguchi",

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year = "2017",

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doi = "10.1016/j.jtos.2016.09.003",

language = "English",

volume = "15",

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Tsubota, K, Yokoi, N, Shimazaki, J, Watanabe, H, Dogru, M, Yamada, M, Kinoshita, S, Kim, HM, Tchah, HW, Hyon, JY, Yoon, KC, Seo, KY, Sun, X, Chen, W, Liang, L, Li, M, Liu, Z, Deng, Y, Hong, J, Jie, Y, Li, Y, Qi, H, Wang, H, Yan, X, Yang, W, Ye, Y, Yuan, J, Zhang, H, Zhan, H, Zhang, M, Zhao, S, Choi, CY, Chung, ES, Kim, HS, Kim, MK, Myoung-Joon, , Kim, TI, Lee, DH, Lee, HK, Song, JS, Amano, S, Arita, R, Hori, Y, Kawakita, T, Kawashima, M, Koh, S, Nishida, K, Ogawa, Y & Yamaguchi, M 2017, 'New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society', Ocular Surface, vol. 15, no. 1, pp. 65-76. https://doi.org/10.1016/j.jtos.2016.09.003

TY - JOUR

T1 - New Perspectives on Dry Eye Definition and Diagnosis

T2 - A Consensus Report by the Asia Dry Eye Society

AU - Tsubota, Kazuo

AU - Yokoi, Norihiko

AU - Shimazaki, Jun

AU - Watanabe, Hitoshi

AU - Dogru, Murat

AU - Yamada, Masakazu

AU - Kinoshita, Shigeru

AU - Kim, Hyo Myung

AU - Tchah, Hung Won

AU - Hyon, Joon Young

AU - Yoon, Kyung Chul

AU - Seo, Kyoung Yul

AU - Sun, Xuguang

AU - Chen, Wei

AU - Liang, Lingyi

AU - Li, Mingwu

AU - Liu, Zuguo

AU - Deng, Yingping

AU - Hong, Jing

AU - Jie, Ying

AU - Li, Ying

AU - Qi, Hong

AU - Wang, Hua

AU - Yan, Xiaoming

AU - Yang, Wenzhao

AU - Ye, Yufeng

AU - Yuan, Jin

AU - Zhang, Hong

AU - Zhan, Hui

AU - Zhang, Mingchang

AU - Zhao, Shaozhen

AU - Choi, Chul Young

AU - Chung, Eui Sang

AU - Kim, Hyun Seung

AU - Kim, Mee Kum

AU - Myoung-Joon,

AU - Kim, Tae Im

AU - Lee, Do Hyung

AU - Lee, Hyung Keun

AU - Song, Jong Suk

AU - Amano, Shiro

AU - Arita, Reiko

AU - Hori, Yuichi

AU - Kawakita, Tetsuya

AU - Kawashima, Motoko

AU - Koh, Shizuka

AU - Nishida, Kohji

AU - Ogawa, Yoko

AU - Yamaguchi, Masahiko

PY - 2017/1/1

Y1 - 2017/1/1

N2 - For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs other than short TFBUT. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: “Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage.” The definition stresses instability of the tear film as well as the importance of visual impairment, highlighting an essential role for TFBUT assessment. This paper discusses the concept of Tear Film Oriented Therapy (TFOT), which evolved from the definition of dry eye, emphasizing the importance of a stable tear film.

AB - For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs other than short TFBUT. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: “Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage.” The definition stresses instability of the tear film as well as the importance of visual impairment, highlighting an essential role for TFBUT assessment. This paper discusses the concept of Tear Film Oriented Therapy (TFOT), which evolved from the definition of dry eye, emphasizing the importance of a stable tear film.

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U2 - 10.1016/j.jtos.2016.09.003

DO - 10.1016/j.jtos.2016.09.003

M3 - Review article

C2 - 27725302

AN - SCOPUS:85006852928

SN - 1542-0124

VL - 15

SP - 65

EP - 76

JO - Ocular Surface

JF - Ocular Surface

IS - 1

ER -

New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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