New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

Yan Lee; Heebeom Koo; Yong Beom Lim; Youngeun Lee; Heejung Mo; Jong Sang Park

doi:10.1016/j.bmcl.2004.02.061

New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

Yan Lee, Heebeom Koo, Yong Beom Lim, Youngeun Lee, Heejung Mo, Jong Sang Park

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by ¹H NMR.

Original language	English
Pages (from-to)	2637-2641
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2004.02.061
Publication status	Published - 2004 May 17

Bibliographical note

Funding Information:
We acknowledge the support of this work by the Korea Research Foundation (2001-015-DP0344), The Korea Science and Engineering Foundation (R02-2002-000-00011-0), and the SRL-Molecular Therapy Research Center, Sunkyunkwan University. We thank Hoyoung Song and Han Kim for their insightful discussions on the synthesis of lipids.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.02.061

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title = "New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives",

abstract = "New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by 1H NMR.",

author = "Yan Lee and Heebeom Koo and Lim, {Yong Beom} and Youngeun Lee and Heejung Mo and Park, {Jong Sang}",

note = "Funding Information: We acknowledge the support of this work by the Korea Research Foundation (2001-015-DP0344), The Korea Science and Engineering Foundation (R02-2002-000-00011-0), and the SRL-Molecular Therapy Research Center, Sunkyunkwan University. We thank Hoyoung Song and Han Kim for their insightful discussions on the synthesis of lipids. ",

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T1 - New cationic lipids for gene transfer with high efficiency and low toxicity

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AU - Lee, Yan

AU - Koo, Heebeom

AU - Lim, Yong Beom

AU - Lee, Youngeun

AU - Mo, Heejung

AU - Park, Jong Sang

N1 - Funding Information: We acknowledge the support of this work by the Korea Research Foundation (2001-015-DP0344), The Korea Science and Engineering Foundation (R02-2002-000-00011-0), and the SRL-Molecular Therapy Research Center, Sunkyunkwan University. We thank Hoyoung Song and Han Kim for their insightful discussions on the synthesis of lipids.

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Y1 - 2004/5/17

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New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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