New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla

Phan Van Kiem; Le Canh Viet Cuong; Do Thi Trang; Nguyen Xuan Nhiem; Hoang Le Tuan Anh; Bui Huu Tai; Le Mai Huong; Chau Van Minh; Taek Hwan Lee; Sun Yeou Kim; Seung Hyun Kim

doi:10.1177/1934578x1701200104

New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla

Phan Van Kiem, Le Canh Viet Cuong, Do Thi Trang, Nguyen Xuan Nhiem, Hoang Le Tuan Anh, Bui Huu Tai, Le Mai Huong, Chau Van Minh, Taek Hwan Lee, Sun Yeou Kim, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPSstimulated NO production in BV2 cells and RAW 264.7 macrophages with IC₅₀ values of 5.4 and 8.0 μM, respectively. Compounds 1-3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC₅₀ values ranging from 11.7 to 77.4 μM.

Original language	English
Pages (from-to)	11-14
Number of pages	4
Journal	Natural product communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1177/1934578x1701200104
Publication status	Published - 2017 Jan

Bibliographical note

Funding Information:
Ministry of Education, Science and Technology (NRF-2011-0025129).

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578x1701200104

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title = "New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla",

abstract = "Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPSstimulated NO production in BV2 cells and RAW 264.7 macrophages with IC50 values of 5.4 and 8.0 μM, respectively. Compounds 1-3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC50 values ranging from 11.7 to 77.4 μM.",

author = "{Van Kiem}, Phan and Cuong, {Le Canh Viet} and Trang, {Do Thi} and Nhiem, {Nguyen Xuan} and Anh, {Hoang Le Tuan} and Tai, {Bui Huu} and Huong, {Le Mai} and Minh, {Chau Van} and Lee, {Taek Hwan} and Kim, {Sun Yeou} and Kim, {Seung Hyun}",

note = "Funding Information: Ministry of Education, Science and Technology (NRF-2011-0025129).",

year = "2017",

month = jan,

doi = "10.1177/1934578x1701200104",

language = "English",

volume = "12",

pages = "11--14",

journal = "Natural product communications",

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T1 - New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla

AU - Van Kiem, Phan

AU - Cuong, Le Canh Viet

AU - Trang, Do Thi

AU - Nhiem, Nguyen Xuan

AU - Anh, Hoang Le Tuan

AU - Tai, Bui Huu

AU - Huong, Le Mai

AU - Minh, Chau Van

AU - Lee, Taek Hwan

AU - Kim, Sun Yeou

AU - Kim, Seung Hyun

N1 - Funding Information: Ministry of Education, Science and Technology (NRF-2011-0025129).

PY - 2017/1

Y1 - 2017/1

N2 - Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPSstimulated NO production in BV2 cells and RAW 264.7 macrophages with IC50 values of 5.4 and 8.0 μM, respectively. Compounds 1-3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC50 values ranging from 11.7 to 77.4 μM.

AB - Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPSstimulated NO production in BV2 cells and RAW 264.7 macrophages with IC50 values of 5.4 and 8.0 μM, respectively. Compounds 1-3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC50 values ranging from 11.7 to 77.4 μM.

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JO - Natural product communications

JF - Natural product communications

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ER -

New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

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