Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury

Kyung Hee Lee; Jin Soo Oh; Yoon Ha; Bae Hwan Lee; William A. Pennant; Do Heum Yoon; Keung Nyun Kim

Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury

Kyung Hee Lee, Jin Soo Oh, Yoon Ha, Bae Hwan Lee, William A. Pennant, Do Heum Yoon, Keung Nyun Kim

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.

Original language	English
Pages (from-to)	477-481
Number of pages	5
Journal	Tissue Engineering and Regenerative Medicine
Volume	8
Issue number	5
Publication status	Published - 2011 Oct

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biomedical Engineering

Cite this

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title = "Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury",

abstract = "We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.",

author = "Lee, {Kyung Hee} and Oh, {Jin Soo} and Yoon Ha and Lee, {Bae Hwan} and Pennant, {William A.} and Yoon, {Do Heum} and Kim, {Keung Nyun}",

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AU - Lee, Kyung Hee

AU - Oh, Jin Soo

AU - Ha, Yoon

AU - Lee, Bae Hwan

AU - Pennant, William A.

AU - Yoon, Do Heum

AU - Kim, Keung Nyun

PY - 2011/10

Y1 - 2011/10

N2 - We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.

AB - We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.

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SN - 1738-2696

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IS - 5

ER -

Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury

Abstract

All Science Journal Classification (ASJC) codes

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