Natural and Synthetic Coral Biomineralization for Human Bone Revitalization

David W. Green, Besim Ben-Nissan, Kyung Sik Yoon, Bruce Milthorpe, Han Sung Jung

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


Coral skeletons can regenerate replacement human bone in nonload-bearing excavated skeletal locations. A combination of multiscale, interconnected pores and channels and highly bioactive surface chemistry has established corals as an important alternative to using healthy host bone replacements. Here, we highlight how coral skeletal systems are being remolded into new calcified structures or synthetic corals by biomimetic processes, as places for the organized permeation of bone tissue cells and blood vessels. Progressive technologies in coral aquaculture and self-organization inorganic chemistry are helping to modify natural corals and create synthetic coral architectures able to accelerate bone regeneration with proper host integration at more skeletal locations, adapted to recent surgical techniques and used to treat intrinsic skeletal deformities and metabolic conditions.

Original languageEnglish
Pages (from-to)43-54
Number of pages12
JournalTrends in Biotechnology
Issue number1
Publication statusPublished - 2017 Jan 1

Bibliographical note

Publisher Copyright:
© 2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering


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