Nanoplasmonic co-localization for highly sensitive surface plasmon resonance detection of molecular interactions

Youngjin Oh, Yonghwi Kim, Wonju Lee, Donghyun Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Surface plasmon resonance (SPR) has been applied to sensing biomolecular and drug interactions because it allows real-time monitoring and label-free detection. Traditional thin film based SPR biosensing suffers from moderate detection sensitivity. In this research, we investigate sensitivity enhancement by target colocalized SPR using various subwavelength nanostructures. The nanostructures were designed by calculating near-field distribution based on rigorous coupled-wave analysis. Experimentally, angled shadow evaporation was performed to fabricate the nanostructures for target colocalization and measured resonance shifts using angle scanning SPR. The feasibility was tested by measuring DNA hybridization. Experimental results confirm significantly enhanced detection sensitivity over traditional SPR techniques to be feasible. The results are expected to open a new approach to biomolecular detection based on SPR.

Original languageEnglish
Title of host publicationPlasmonics in Biology and Medicine X
Publication statusPublished - 2013
EventPlasmonics in Biology and Medicine X - San Francisco, CA, United States
Duration: 2013 Feb 32013 Feb 4

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPlasmonics in Biology and Medicine X
Country/TerritoryUnited States
CitySan Francisco, CA

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Nanoplasmonic co-localization for highly sensitive surface plasmon resonance detection of molecular interactions'. Together they form a unique fingerprint.

Cite this