TY - JOUR
T1 - Nanoparticle interaction with biological membranes
T2 - Does nanotechnology present a janus face?
AU - Leroueil, Pascale R.
AU - Hong, Seungpyo
AU - Mecke, Almut
AU - Baker, James R.
AU - Orr, Bradford G.
AU - Holl, Mark M.Banaszak
PY - 2007/5
Y1 - 2007/5
N2 - Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phase-fluid, liquid crystalline, or gel-of the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microsopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy.
AB - Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phase-fluid, liquid crystalline, or gel-of the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microsopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy.
UR - http://www.scopus.com/inward/record.url?scp=34447636787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447636787&partnerID=8YFLogxK
U2 - 10.1021/ar600012y
DO - 10.1021/ar600012y
M3 - Article
C2 - 17474708
AN - SCOPUS:34447636787
SN - 0001-4842
VL - 40
SP - 335
EP - 342
JO - Accounts of Chemical Research
JF - Accounts of Chemical Research
IS - 5
ER -