Abstract
Photodynamic therapy (PDT) is a cytotoxic treatment using singlet oxygen produced by photosensitizers. Approved porphyrinoid PDT still suffers from a lack of robust production methods and low water solubility. Methylene blue (MB) is a good candidate for the PDT drug, because the dye is an effective photosensitizer, can be easily synthesized, and is already being used in other clinical fields. However, its poor cell/tissue penetration and low stability against the reducible biological conditions should be addressed by using a proper delivery vehicle. Here, we employed a DNA tetrahedron, a self-assembled nanostructure as the carrier for intracellular delivery of MB by taking advantage of the DNA binding property of the photosensitizer and demonstrated photo-induced cytotoxicity by the MB delivered by the DNA nanocarrier. We also evaluated the PDT potency of the MB-loaded DNA nanoconstruct in vivo tumor model to suppress tumor growth.
Original language | English |
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Pages (from-to) | 605-609 |
Number of pages | 5 |
Journal | Biomaterials Science |
Volume | 4 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2016 Apr |
Bibliographical note
Publisher Copyright:© 2016 The Royal Society of Chemistry.
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Materials Science(all)