TY - JOUR
T1 - Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death
AU - Park, Sungjin
AU - Kim, Minhee
AU - Hong, Youngeun
AU - Lee, Hyunji
AU - Tran, Quangdon
AU - Kim, Chaeyeong
AU - Kwon, So Hee
AU - Park, Jisoo
AU - Park, Jongsun
AU - Kim, Seon Hwan
N1 - Publisher Copyright:
© 2020, Korean Society of Toxicology.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Lung cancer is the most common cause of cancer-associated death worldwide. Most patients with non-small cell lung cancer die within several years of the initial diagnosis, and new therapies are desperately needed. Transmembrane protein (TMEM) 39AS41, a synthetic peptide, was generated from the protein kinase B substrate motif 34GLRNRNGSAIGLPVP48 found in the human TMEM39A protein. Myristic acid was conjugated to the N-terminus of the peptide to confer cell permeability. In this study, we found that in vitro TMEM39AS41 peptide led to cell death via inhibition of inflammation/autophagy pathways in KRAS-mutated cell and tissues. In addition, TMEM39A, at a dose of 30 mg/kg, significantly suppressed tumor growth in KRASLA1 non-small cell lung cancer mice. These results suggest that the TMEM39AS41 peptide could have therapeutic potential for lung cancer.
AB - Lung cancer is the most common cause of cancer-associated death worldwide. Most patients with non-small cell lung cancer die within several years of the initial diagnosis, and new therapies are desperately needed. Transmembrane protein (TMEM) 39AS41, a synthetic peptide, was generated from the protein kinase B substrate motif 34GLRNRNGSAIGLPVP48 found in the human TMEM39A protein. Myristic acid was conjugated to the N-terminus of the peptide to confer cell permeability. In this study, we found that in vitro TMEM39AS41 peptide led to cell death via inhibition of inflammation/autophagy pathways in KRAS-mutated cell and tissues. In addition, TMEM39A, at a dose of 30 mg/kg, significantly suppressed tumor growth in KRASLA1 non-small cell lung cancer mice. These results suggest that the TMEM39AS41 peptide could have therapeutic potential for lung cancer.
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U2 - 10.1007/s43188-020-00038-1
DO - 10.1007/s43188-020-00038-1
M3 - Article
AN - SCOPUS:85079631734
SN - 1976-8257
VL - 36
SP - 123
EP - 130
JO - Toxicological Research
JF - Toxicological Research
IS - 2
ER -
