Mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes

Yun Hee Choi; Dong Joo Yang; Atul Kulkarni; Sang Hyun Moh; Ki Woo Kim

doi:10.3390/md13127056

Mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes

Yun Hee Choi, Dong Joo Yang, Atul Kulkarni, Sang Hyun Moh, Ki Woo Kim

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In addition, MAAs are also involved in the modulation of skin fibroblasts proliferation. However, the regulatory function of MAAs on wound repair in human skin is not yet clearly elucidated. To investigate the roles of MAAs on the wound healing process in human keratinocytes, three MAAs, Shinorine (SH), Mycosporine-glycine (M-Gly), and Porphyra (P334) were purified from Chlamydomonas hedlyei and Porphyra yezoensis. We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. This study also indicates that MAAs can act as a new wound healing agent and further suggests that MAAs might be a novel biomaterial for wound healing therapies.

Original language	English
Pages (from-to)	7055-7066
Number of pages	12
Journal	Marine Drugs
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/md13127056
Publication status	Published - 2015 Dec 1

Bibliographical note

Funding Information:
Acknowledgments: We would like to thank Ann W. Kinyua (Yonsei University) for the critical reading of this manuscript. This research was a part of the project titled “Development and Industrialization of Marine derived MAA for Anti-aging Cosmetic Products (20150071)” funded by the Ministry of Oceans and Fisheries (for S.H.M). Data presented in this paper were also supported by the Global Ph. D Fellowship (NRF-2015H1A2A1032009 for D.J.Y.) and National Research Foundation (NRF-2013R1A1A1007693 and 2014K1A3A1A19066980 for K.W.K).

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md13127056

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title = "Mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes",

abstract = "Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In addition, MAAs are also involved in the modulation of skin fibroblasts proliferation. However, the regulatory function of MAAs on wound repair in human skin is not yet clearly elucidated. To investigate the roles of MAAs on the wound healing process in human keratinocytes, three MAAs, Shinorine (SH), Mycosporine-glycine (M-Gly), and Porphyra (P334) were purified from Chlamydomonas hedlyei and Porphyra yezoensis. We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. This study also indicates that MAAs can act as a new wound healing agent and further suggests that MAAs might be a novel biomaterial for wound healing therapies.",

author = "Choi, {Yun Hee} and Yang, {Dong Joo} and Atul Kulkarni and Moh, {Sang Hyun} and Kim, {Ki Woo}",

note = "Funding Information: Acknowledgments: We would like to thank Ann W. Kinyua (Yonsei University) for the critical reading of this manuscript. This research was a part of the project titled “Development and Industrialization of Marine derived MAA for Anti-aging Cosmetic Products (20150071)” funded by the Ministry of Oceans and Fisheries (for S.H.M). Data presented in this paper were also supported by the Global Ph. D Fellowship (NRF-2015H1A2A1032009 for D.J.Y.) and National Research Foundation (NRF-2013R1A1A1007693 and 2014K1A3A1A19066980 for K.W.K). Publisher Copyright: {\textcopyright} 2015 by the authors; licensee MDPI, Basel, Switzerland.",

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AU - Moh, Sang Hyun

AU - Kim, Ki Woo

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PY - 2015/12/1

Y1 - 2015/12/1

N2 - Mycosporine-like amino acids (MAAs) are secondary metabolites found in diverse marine, freshwater, and terrestrial organisms. Evidence suggests that MAAs have several beneficial effects on skin homeostasis such as protection against UV radiation and reactive oxygen species (ROS). In addition, MAAs are also involved in the modulation of skin fibroblasts proliferation. However, the regulatory function of MAAs on wound repair in human skin is not yet clearly elucidated. To investigate the roles of MAAs on the wound healing process in human keratinocytes, three MAAs, Shinorine (SH), Mycosporine-glycine (M-Gly), and Porphyra (P334) were purified from Chlamydomonas hedlyei and Porphyra yezoensis. We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. This study also indicates that MAAs can act as a new wound healing agent and further suggests that MAAs might be a novel biomaterial for wound healing therapies.

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Mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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