Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Yeon Hee Ban; Jong Hyun Lee; Gyo Rim Gu; Boram Lee; Sangjoon Mo; Ho Jeong Kwon; Yeo Joon Yoon

doi:10.1039/c2mb25419k

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Yeon Hee Ban, Jong Hyun Lee, Gyo Rim Gu, Boram Lee, Sangjoon Mo, Ho Jeong Kwon, Yeo Joon Yoon

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.

Original language	English
Pages (from-to)	944-947
Number of pages	4
Journal	Molecular BioSystems
Volume	9
Issue number	5
DOIs	https://doi.org/10.1039/c2mb25419k
Publication status	Published - 2013 May

All Science Journal Classification (ASJC) codes

Biotechnology
Molecular Biology

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abstract = "A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.",

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AU - Mo, Sangjoon

AU - Kwon, Ho Jeong

AU - Yoon, Yeo Joon

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Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

Abstract

All Science Journal Classification (ASJC) codes

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