Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement

Ji Yeong Kim, Woojin Choi, Utkarsh Mangal, Ji Young Seo, Tae Yun Kang, Joohee Lee, Taeho Kim, Jung Yul Cha, Kee Joon Lee, Kwang Mahn Kim, Jin Man Kim, Dohyun Kim, Jae Sung Kwon, Jinkee Hong, Sung Hwan Choi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Polyalkenoate cement (PAC) is a promising material for regenerative hard tissue therapy. The ionically rich glass component of PAC encourages bioactive interaction via. the release of essential ions. However, PAC bioactivity is restricted owing to (i) structurally inherent cationic network formers and (ii) surface bacterial biofilm formation. These two factors cause a deficiency in ion release, further complicated by secondary infections and premature therapeutic failure. Here, a multivalent zwitterionic network modifier (mZM) is presented for upregulation of ionic exchange and bioactivity enhancement. By introducing a non-zero charged mZM into PACs, an increase in the proportion of non-bridging oxygen occurs. The network modification promotes ion channel formation, causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite (ca. 74%). Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the mZM. Furthermore, divalent cationic interaction results in bacterial biofilm reduction (ca. 68%) while also influencing a shift in the biofilm species composition, which favors commensal growth. Therefore, PAC modification with mZM offers a promising solution for upregulation of bioactivity, even aiding in customization by targeting site-specific regenerative therapy in future applications.

Original languageEnglish
Pages (from-to)219-233
Number of pages15
JournalBioactive Materials
Publication statusPublished - 2022 Aug

Bibliographical note

Publisher Copyright:
© 2021 The Authors

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement'. Together they form a unique fingerprint.

Cite this