Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in cryptococcus neoformans

Jang Won Lee; Young Joon Ko; Seo Young Kim; Yong Sun Bahn

doi:10.1128/EC.05124-11

Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in cryptococcus neoformans

Jang Won Lee, Young Joon Ko, Seo Young Kim, Yong Sun Bahn

Research output: Contribution to journal › Comment/debate › peer-review

37 Citations (Scopus)

Abstract

Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner.

Original language	English
Pages (from-to)	998-1002
Number of pages	5
Journal	Eukaryotic Cell
Volume	10
Issue number	7
DOIs	https://doi.org/10.1128/EC.05124-11
Publication status	Published - 2011 Jul

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Biology

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abstract = "Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner.",

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Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in cryptococcus neoformans

Abstract

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