Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement

Huiyul Park; Jaemoon Yang; Sungbaek Seo; Kyujung Kim; Jinsuk Suh; Donghyun Kim; Seungjoo Haam; Kyung Hwa Yoo

doi:10.1002/smll.200700807

Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement

Huiyul Park, Jaemoon Yang, Sungbaek Seo, Kyujung Kim, Jinsuk Suh, Donghyun Kim, Seungjoo Haam, Kyung Hwa Yoo

Research output: Contribution to journal › Article › peer-review

149 Citations (Scopus)

Abstract

The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.

Original language	English
Pages (from-to)	192-196
Number of pages	5
Journal	Small
Volume	4
Issue number	2
DOIs	https://doi.org/10.1002/smll.200700807
Publication status	Published - 2008 Feb

All Science Journal Classification (ASJC) codes

Biotechnology
Chemistry(all)
Biomaterials
Materials Science(all)

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10.1002/smll.200700807

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abstract = "The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.",

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AU - Park, Huiyul

AU - Yang, Jaemoon

AU - Seo, Sungbaek

AU - Kim, Kyujung

AU - Suh, Jinsuk

AU - Kim, Donghyun

AU - Haam, Seungjoo

AU - Yoo, Kyung Hwa

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AB - The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.

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Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement

Abstract

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