Multifunctional nanoparticles for combined doxorubicin and photothermal treatments

Huiyul Park; Jaemoon Yang; Jaemin Lee; Seungjoo Haam; In Hong Choi; Kyung Hwa Yoo

doi:10.1021/nn900215k

Multifunctional nanoparticles for combined doxorubicin and photothermal treatments

Huiyul Park, Jaemoon Yang, Jaemin Lee, Seungjoo Haam, In Hong Choi, Kyung Hwa Yoo

Research output: Contribution to journal › Article › peer-review

326 Citations (Scopus)

Abstract

To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicinloaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.

Original language	English
Pages (from-to)	2919-2926
Number of pages	8
Journal	ACS Nano
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/nn900215k
Publication status	Published - 2009 Oct 27

All Science Journal Classification (ASJC) codes

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/nn900215k

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AU - Park, Huiyul

AU - Yang, Jaemoon

AU - Lee, Jaemin

AU - Haam, Seungjoo

AU - Choi, In Hong

AU - Yoo, Kyung Hwa

PY - 2009/10/27

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AB - To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicinloaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA-Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the PLGA NPs biodegraded, DOX was released, and heat was locally generated upon near-infrared (NIR) irradiation due to NIR resonance of DOX-loaded PLGA H-S NPs. Compared with chemotherapy or photothermal treatment alone, the combined treatment demonstrated a synergistic effect, resulting in higher therapeutic efficacy and shorter treatment times. Since our NPs selectively deliver both heat and drug to tumorigenic regions, they may improve the therapeutic effectiveness with minimal side effects.

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Multifunctional nanoparticles for combined doxorubicin and photothermal treatments

Abstract

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