Multifocal adenocarcinomas arising within a gastric inverted hyperplastic polyp

Hyun Soo Kim, Eun Jung Hwang, Jae Young Jang, Juhie Lee, Youn Wha Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We present herein the occurrence of multifocal adenocarcinomas with a minute signet ring cell carcinoma that arose within a gastric inverted hyperplastic polyp (IHP) in a 40-year-old woman. Endoscopic ultrasonography demonstrated a heterogeneous hypoechoic mass in the third layer of the gastric wall. The endoscopic submucosal dissection specimen measuring 3.5×3.2×1.8 cm was a well-circumscribed protruding lesion that had a slit-shaped cavity. Histologically, the lesion consisted mainly of endophytic proliferation of hyperplastic columnar cells resembling normal foveolar epithelium. In addition, six foci of adenocarcinomas and a minute focus of signet ring cell carcinoma were randomly distributed in the superficial and deep regions. The adenocarcinoma was gradually transitioning from dysplasia, while the signet ring cell carcinoma was surrounded by hyperplastic foveolar epithelium. This is the first report of a gastric IHP with multifocal intramucosal adenocarcinomas and a signet ring cell carcinoma, and endoscopic submucosal dissection is used to completely resect it.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalKorean Journal of Pathology
Issue number4
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


Dive into the research topics of 'Multifocal adenocarcinomas arising within a gastric inverted hyperplastic polyp'. Together they form a unique fingerprint.

Cite this