Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high-volume Eastern centers and the SEER database

Taeil Son; Jiyu Sun; Seohee Choi; Minah Cho; In Gyu Kwon; Hyoung Il Kim; Jae Ho Cheong; Seung Ho Choi; Sung Hoon Noh; Yanghee Woo; Yuman Fong; Sohee Park; Woo Jin Hyung

doi:10.1002/jso.25639

Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high-volume Eastern centers and the SEER database

Taeil Son, Jiyu Sun, Seohee Choi, Minah Cho, In Gyu Kwon, Hyoung Il Kim, Jae Ho Cheong, Seung Ho Choi, Sung Hoon Noh, Yanghee Woo, Yuman Fong, Sohee Park, Woo Jin Hyung

Department of Surgery

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.

Original language	English
Pages (from-to)	676-684
Number of pages	9
Journal	Journal of surgical oncology
Volume	120
Issue number	4
DOIs	https://doi.org/10.1002/jso.25639
Publication status	Published - 2019

Bibliographical note

Funding Information:
We would like to thank Anthony Thomas Milliken, ELS (Editing Synthase, Seoul, Korea) for his assistance with editing the manuscript. We also acknowledge the assistance of BioScience Writers, LLC (Houston, TX) with copyediting and correction of English language usage. This study was supported by a grant from the Investigator Sponsored Research Program (ISR‐2017‐10924, Covidien Private Limited [Medtronic]). This funding source had no role in the design of this study nor any role during its execution, data analyses and interpretation, or decision to submit results for presentation or publication.

Funding Information:
We would like to thank Anthony Thomas Milliken, ELS (Editing Synthase, Seoul, Korea) for his assistance with editing the manuscript. We also acknowledge the assistance of BioScience Writers, LLC (Houston, TX) with copyediting and correction of English language usage. This study was supported by a grant from the Investigator Sponsored Research Program (ISR-2017-10924, Covidien Private Limited [Medtronic]). This funding source had no role in the design of this study nor any role during its execution, data analyses and interpretation, or decision to submit results for presentation or publication.

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.25639

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Son, T., Sun, J., Choi, S., Cho, M., Kwon, I. G., Kim, H. I., Cheong, J. H., Choi, S. H., Noh, S. H., Woo, Y., Fong, Y., Park, S., & Hyung, W. J. (2019). Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high-volume Eastern centers and the SEER database. Journal of surgical oncology, 120(4), 676-684. https://doi.org/10.1002/jso.25639

@article{683e57a245c24fe29c35b439ff0b4f8b,

title = "Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high-volume Eastern centers and the SEER database",

abstract = "Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.",

author = "Taeil Son and Jiyu Sun and Seohee Choi and Minah Cho and Kwon, {In Gyu} and Kim, {Hyoung Il} and Cheong, {Jae Ho} and Choi, {Seung Ho} and Noh, {Sung Hoon} and Yanghee Woo and Yuman Fong and Sohee Park and Hyung, {Woo Jin}",

note = "Funding Information: We would like to thank Anthony Thomas Milliken, ELS (Editing Synthase, Seoul, Korea) for his assistance with editing the manuscript. We also acknowledge the assistance of BioScience Writers, LLC (Houston, TX) with copyediting and correction of English language usage. This study was supported by a grant from the Investigator Sponsored Research Program (ISR‐2017‐10924, Covidien Private Limited [Medtronic]). This funding source had no role in the design of this study nor any role during its execution, data analyses and interpretation, or decision to submit results for presentation or publication. Funding Information: We would like to thank Anthony Thomas Milliken, ELS (Editing Synthase, Seoul, Korea) for his assistance with editing the manuscript. We also acknowledge the assistance of BioScience Writers, LLC (Houston, TX) with copyediting and correction of English language usage. This study was supported by a grant from the Investigator Sponsored Research Program (ISR-2017-10924, Covidien Private Limited [Medtronic]). This funding source had no role in the design of this study nor any role during its execution, data analyses and interpretation, or decision to submit results for presentation or publication. Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

doi = "10.1002/jso.25639",

language = "English",

volume = "120",

pages = "676--684",

journal = "Journal of surgical oncology",

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Son, T, Sun, J, Choi, S, Cho, M, Kwon, IG, Kim, HI, Cheong, JH, Choi, SH, Noh, SH, Woo, Y, Fong, Y, Park, S & Hyung, WJ 2019, 'Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high-volume Eastern centers and the SEER database', Journal of surgical oncology, vol. 120, no. 4, pp. 676-684. https://doi.org/10.1002/jso.25639

TY - JOUR

T1 - Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer

T2 - Analysis of survival data from high-volume Eastern centers and the SEER database

AU - Son, Taeil

AU - Sun, Jiyu

AU - Choi, Seohee

AU - Cho, Minah

AU - Kwon, In Gyu

AU - Kim, Hyoung Il

AU - Cheong, Jae Ho

AU - Choi, Seung Ho

AU - Noh, Sung Hoon

AU - Woo, Yanghee

AU - Fong, Yuman

AU - Park, Sohee

AU - Hyung, Woo Jin

N1 - Funding Information: We would like to thank Anthony Thomas Milliken, ELS (Editing Synthase, Seoul, Korea) for his assistance with editing the manuscript. We also acknowledge the assistance of BioScience Writers, LLC (Houston, TX) with copyediting and correction of English language usage. This study was supported by a grant from the Investigator Sponsored Research Program (ISR‐2017‐10924, Covidien Private Limited [Medtronic]). This funding source had no role in the design of this study nor any role during its execution, data analyses and interpretation, or decision to submit results for presentation or publication. Funding Information: We would like to thank Anthony Thomas Milliken, ELS (Editing Synthase, Seoul, Korea) for his assistance with editing the manuscript. We also acknowledge the assistance of BioScience Writers, LLC (Houston, TX) with copyediting and correction of English language usage. This study was supported by a grant from the Investigator Sponsored Research Program (ISR-2017-10924, Covidien Private Limited [Medtronic]). This funding source had no role in the design of this study nor any role during its execution, data analyses and interpretation, or decision to submit results for presentation or publication. Publisher Copyright: © 2019 Wiley Periodicals, Inc.

PY - 2019

Y1 - 2019

N2 - Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.

AB - Background: The clinical relevance and general applicability of the 8th American Joint Committee on Cancer TNM gastric cancer staging system vs the 7th version have not been examined using datasets from both the East and West. Methods: Patients (n = 29 984) treated for gastric adenocarcinoma at two high-volume centers (Severance Hospital [SH] and Gangnam Severance Hospital [GSH]) in Korea and data from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively analyzed. Survival curves, the performance of tumor staging, and the homogeneity of modified subgroups were compared. Results: Minute changes were noted in the stage IIB subgroup; most changes were noted in stage III. Applying the 8th staging system facilitated better prediction of survival than applying the 7th version for SH data according to the log-rank test, C-index, and AIC (8444.5 vs 9263.8, 0.796 vs 0.798, and 104152 vs 103909, respectively). Its performance was also superior for GSH and SEER data. In a subgroup analysis of stages IIB to IIIC in SH, GSH, and SEER data, the 8th staging system showed similar or more homogeneous survival for each sub-classification than the 7th version. Conclusion: Compared with the 7th gastric cancer staging system, the newer version more accurately predicted prognosis and stratified subgroups more homogeneously.

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U2 - 10.1002/jso.25639

DO - 10.1002/jso.25639

M3 - Article

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JO - Journal of surgical oncology

JF - Journal of surgical oncology

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Multi-institutional validation of the 8th AJCC TNM staging system for gastric cancer: Analysis of survival data from high-volume Eastern centers and the SEER database

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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