Background/Purpose: The current study aimed to develop a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic ductal adenocarcinoma. Methods: Multi-center cohort of 1991 blood samples were collected from January 2011 to September 2019, of which 609 were normal, 145 were other cancer (colorectal, thyroid, and breast cancer), 314 were pancreatic benign disease, and 923 were pancreatic ductal adenocarcinoma. The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed using three potential biomarkers: LRG1, TTR, and CA 19-9. Using a logistic regression model on a training data set, the predicted values for pancreatic ductal adenocarcinoma were obtained, and the result was classification into one of the three risk groups: low, intermediate, and high. The five covariates used to create the model were sex, age, and three biomarkers. Results: Participants were categorized into four groups as normal (n = 609), other cancer (n = 145), pancreatic benign disease (n = 314), and pancreatic ductal adenocarcinoma (n = 923). The normal, other cancer, and pancreatic benign disease groups were clubbed into the non-pancreatic ductal adenocarcinoma group (n = 1068). The positive and negative predictive value, sensitivity, and specificity were 94.12, 90.40, 93.81, and 90.86, respectively. Conclusions: This study demonstrates a significant diagnostic performance of the multi-marker panel in distinguishing pancreatic ductal adenocarcinoma from normal and benign pancreatic disease states, as well as patients with other cancers.
|Number of pages||11|
|Journal||Journal of Hepato-Biliary-Pancreatic Sciences|
|Publication status||Published - 2023 Jan|
Bibliographical noteFunding Information:
The bio-specimens and data used in this study were provided by the Biobank of Seoul National University Hospital, a member of the Korea Biobank Network (SNUH No. 2018-0070, 2019-0107, 2020-0012). The bio-specimens for this study were provided by Samsung Medical Center BioBank. This study was funded by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C2640).
The bio‐specimens and data used in this study were provided by the Biobank of Seoul National University Hospital, a member of the Korea Biobank Network (SNUH No. 2018‐0070, 2019‐0107, 2020‐0012). The bio‐specimens for this study were provided by Samsung Medical Center BioBank. This study was funded by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C2640).
© 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
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