Msi1-like (MSIL) proteins in fungi

Dong Hoon Yang, Shinae Maeng, Yong Sun Bahn

Research output: Contribution to journalShort surveypeer-review

7 Citations (Scopus)


Msi1-like (MSIL) proteins, which are eukaryote-specific and contain a series of WD40repeats, have pleiotropic roles in chromatin assembly, DNA damage repair, and regulation of nutrient/stress-sensing signaling pathways. In the fungal kingdom, the functions of MSIL proteins have been studied most intensively in the budding yeast model Saccharomyces cerevisiae, an ascomycete. Yet their functions are largely unknown in other fungi. Recently, an MSIL protein, Msl1, was discovered and functionally characterized in the pathogenicyeast Cryptococcus neoformans, a basidiomycete. Interestingly, MSIL proteins appear to have redundant and unique roles in both fungi, suggesting that MSIL proteins may have evolutionarily divergent roles in different parts of the fungal kingdom. In this review, we will describe the current findings regarding the role of MSIL proteins in fungi and discussfuture directions for research on this topic.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
Issue number1
Publication statusPublished - 2013 Mar

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases


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