Mri-visible perivascular spaces in the centrum semiovale are associated with brain amyloid deposition in patients with alzheimer disease-related cognitive impairment

H. J. Kim, H. Cho, M. Park, J. W. Kim, S. J. Ahn, C. H. Lyoo, S. H. Suh, Y. H. Ryu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease-related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease-related cognitive impairment and β-amyloid deposition, assessed with [18F] florbetaben PET/CT. MATERIALS AND METHODS: MR imaging and [18F] florbetaben PET/CT images of 144 patients with Alzheimer disease-related cognitive impairment were retrospectively evaluated. MR imaging-visible perivascular spaces were rated on a 4-point visual scale: A score of ≥3 or ,3 indicated a high or low degree of MR imaging-visible perivascular spaces, respectively. Amyloid deposition was evaluated using the brain β -amyloid plaque load scoring system. RESULTS: Compared with patients negative for β -amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the Apolipoprotein E 4 allele, and a high degree of MR imaging-visible perivascular spaces in the centrum semiovale. Multivariable analysis, adjusted for age and Apolipoprotein E status, revealed that a high degree of MR imaging-visible perivascular spaces in the centrum semiovale was independently associated with β -amyloid positivity (odds ratio, 2.307; 95% CI, 1.036-5.136; P=.041). CONCLUSIONS: A high degree of MR imaging-visible perivascular spaces in the centrum semiovale independently predicted β -amyloid positivity in patients with Alzheimer disease-related cognitive impairment. Thus, MR imaging-visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease-related cognitive impairment.

Original languageEnglish
Pages (from-to)1231-1238
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume42
Issue number7
DOIs
Publication statusPublished - 2021 Jul 1

Bibliographical note

Publisher Copyright:
© 2021 American Society of Neuroradiology. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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