Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells

So Yeop Han, So Hye Cho, So Yeon Kim, Jeong Taeg Seo, Seok Jun Moon, Gil Ja Jhon

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - 1999 Jan

Bibliographical note

Funding Information:
Acknowledgements The financial support for this work from the Korean Ministry of Education through Research Fund (BSRI-97-3422, BSRI-97-3442) and MOST through the Women's University Research Fund (1997) is gratefully appreciated.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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