Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells

So Yeop Han; So Hye Cho; So Yeon Kim; Jeong Taeg Seo; Seok Jun Moon; Gil Ja Jhon

doi:10.1016/S0960-894X(98)00690-8

Monoacetyldiglycerides as new Ca²⁺ mobilizing agents in rat pancreatic acinar cells

So Yeop Han, So Hye Cho, So Yeon Kim, Jeong Taeg Seo, Seok Jun Moon, Gil Ja Jhon

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca²⁺ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca²⁺ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.

Original language	English
Pages (from-to)	59-64
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(98)00690-8
Publication status	Published - 1999 Jan

Bibliographical note

Funding Information:
Acknowledgements The financial support for this work from the Korean Ministry of Education through Research Fund (BSRI-97-3422, BSRI-97-3442) and MOST through the Women's University Research Fund (1997) is gratefully appreciated.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(98)00690-8

Cite this

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title = "Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells",

abstract = "Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.",

author = "Han, {So Yeop} and Cho, {So Hye} and Kim, {So Yeon} and Seo, {Jeong Taeg} and Moon, {Seok Jun} and Jhon, {Gil Ja}",

note = "Funding Information: Acknowledgements The financial support for this work from the Korean Ministry of Education through Research Fund (BSRI-97-3422, BSRI-97-3442) and MOST through the Women's University Research Fund (1997) is gratefully appreciated.",

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AU - Cho, So Hye

AU - Kim, So Yeon

AU - Seo, Jeong Taeg

AU - Moon, Seok Jun

AU - Jhon, Gil Ja

N1 - Funding Information: Acknowledgements The financial support for this work from the Korean Ministry of Education through Research Fund (BSRI-97-3422, BSRI-97-3442) and MOST through the Women's University Research Fund (1997) is gratefully appreciated.

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