Molybdenum disulfide (MoS2) nanoflakes as inherently electroactive labels for DNA hybridization detection

Adeline Huiling Loo, Alessandra Bonanni, Adriano Ambrosi, Martin Pumera

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)


The detection of specific DNA sequences plays a critical role in the areas of medical diagnostics, environmental monitoring, drug discovery and food safety. This has therefore become a strong driving force behind the ever-increasing demand for simple, cost-effective, highly sensitive and selective DNA biosensors. In this study, we report for the first time, a novel approach for the utilization of molybdenum disulfide nanoflakes, a member of the transition metal dichalcogenides family, in the detection of DNA hybridization. Herein, molybdenum disulfide nanoflakes serve as inherently electroactive labels, with the inherent oxidation peak exploited as the analytical signal. The principle of detection is based on the differential affinity of molybdenum disulfide nanoflakes towards single-stranded DNA and double-stranded DNA. The employment of transition metal dichalcogenide nanomaterials for sensing and biosensing purposes represents an upcoming research area which holds great promise. Hence, our findings are anticipated to have significant contributions towards the fabrication of future DNA biosensors.

Original languageEnglish
Pages (from-to)11971-11975
Number of pages5
Issue number20
Publication statusPublished - 2014 Oct 21

Bibliographical note

Publisher Copyright:
© 2014 the Partner Organisations 2014.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)


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