Molecular imaging of CD44-overexpressing gastric cancer in mice using T2 MR imaging

Hwunjae Lee, Seung Hyun Yang, Dan Heo, Heyoung Son, Seungjoo Haam, Jin Suck Suh, Jaemoon Yang, Yong Min Huh

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10 Citations (Scopus)


Novel diagnostic techniques have been developed in many research area using targetable contrast agents with magnetic resonance imaging (MRI) for cancer diagnosis. For cancer diagnosis, the use of MRI with biocompatible targeting moieties and manganese ferrite nanoparticles (MFNPs) is preferred. Thus, we synthesized MFNPs using a thermal decomposition method which enables sensitive T2 or T2 Turbo Spin Echo (TSE) MRI and coated them with hyaluronic acid (HA). The high targeting ability of HA-MFNPs was observed at MKN-45 cells (gastric cancer cell line) which high-expressing CD44 in contrast with MKN-28 cells which low-expressing CD44. We also prepared the gastric cancer mice model using MKN-45 cells which has the stem-like property was implanted into BALB/c nude mice. And then HA-MFNPs of the T2 contrast enhancement effects and targeting ability were investigated by in vivo MR imaging. As a result of these studies, we conclude that HA coated MFNPs can be effectively used as a novel probes for visualizing gastric cancer stem cells.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Issue number1
Publication statusPublished - 2016 Jan 1

Bibliographical note

Funding Information:
This work was supported by the Nation Research Foundation grant (2006-2004652) funded by the Korea government (MEST)/grant from the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea (1220100)/the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2014R1A1A2059806).

Publisher Copyright:
Copyright © 2016 American Scientific Publishers. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics


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