Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

Soo Mee Bang; Ji Weon Seo; Kyung Un Park; Seok Jin Kim; Kihyun Kim; Sun Hee Kim; Sung Ran Cho; Hugh C. Kim; Jaewoo Song; Jin Seok Kim; Kyung Hee Kim; Jae Hoon Lee; Je Jung Lee; Myung Geun Shin; Cheolwon Suh; Hyun Sook Chi; Do yeun Oh; Jong Ho Won; Hyo Jung Kim; Sung Soo Yoon; Dong Soon Lee

doi:10.1016/j.cancergencyto.2009.11.008

Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

Soo Mee Bang, Ji Weon Seo, Kyung Un Park, Seok Jin Kim, Kihyun Kim, Sun Hee Kim, Sung Ran Cho, Hugh C. Kim, Jaewoo Song, Jin Seok Kim, Kyung Hee Kim, Jae Hoon Lee, Je Jung Lee, Myung Geun Shin, Cheolwon Suh, Hyun Sook Chi, Do yeun Oh, Jong Ho Won, Hyo Jung Kim, Sung Soo YoonDong Soon Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

Original language	English
Pages (from-to)	117-121
Number of pages	5
Journal	Cancer genetics and cytogenetics
Volume	197
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.11.008
Publication status	Published - 2010 Mar

Bibliographical note

Funding Information:
This work was supported in part by the National R&D Program for Cancer Control, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( 0720440 ); Seoul National University Hospital Clinical Research Institute ( 04-2008-024-0 ); and the Korea Science and Engineering Foundation (KOSEF) funded by the Ministry of Education, Science, and Technology, Korea ( M1064152000106N415200110 ).

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cancergencyto.2009.11.008

Cite this

Bang, S. M., Seo, J. W., Park, K. U., Kim, S. J., Kim, K., Kim, S. H., Cho, S. R., Kim, H. C., Song, J., Kim, J. S., Kim, K. H., Lee, J. H., Lee, J. J., Shin, M. G., Suh, C., Chi, H. S., Oh, D. Y., Won, J. H., Kim, H. J., ... Lee, D. S. (2010). Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia. Cancer genetics and cytogenetics, 197(2), 117-121. https://doi.org/10.1016/j.cancergencyto.2009.11.008

@article{00df9fe76aba4dae9010c509e928b02f,

title = "Molecular cytogenetic analysis of Korean patients with Waldenstr{\"o}m macroglobulinemia",

abstract = "To compare the molecular cytogenetic characteristics between Waldenstr{\"o}m macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.",

author = "Bang, {Soo Mee} and Seo, {Ji Weon} and Park, {Kyung Un} and Kim, {Seok Jin} and Kihyun Kim and Kim, {Sun Hee} and Cho, {Sung Ran} and Kim, {Hugh C.} and Jaewoo Song and Kim, {Jin Seok} and Kim, {Kyung Hee} and Lee, {Jae Hoon} and Lee, {Je Jung} and Shin, {Myung Geun} and Cheolwon Suh and Chi, {Hyun Sook} and Oh, {Do yeun} and Won, {Jong Ho} and Kim, {Hyo Jung} and Yoon, {Sung Soo} and Lee, {Dong Soon}",

note = "Funding Information: This work was supported in part by the National R&D Program for Cancer Control, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( 0720440 ); Seoul National University Hospital Clinical Research Institute ( 04-2008-024-0 ); and the Korea Science and Engineering Foundation (KOSEF) funded by the Ministry of Education, Science, and Technology, Korea ( M1064152000106N415200110 ).",

year = "2010",

month = mar,

doi = "10.1016/j.cancergencyto.2009.11.008",

language = "English",

volume = "197",

pages = "117--121",

journal = "Cancer genetics and cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "2",

}

Bang, SM, Seo, JW, Park, KU, Kim, SJ, Kim, K, Kim, SH, Cho, SR, Kim, HC, Song, J, Kim, JS, Kim, KH, Lee, JH, Lee, JJ, Shin, MG, Suh, C, Chi, HS, Oh, DY, Won, JH, Kim, HJ, Yoon, SS & Lee, DS 2010, 'Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia', Cancer genetics and cytogenetics, vol. 197, no. 2, pp. 117-121. https://doi.org/10.1016/j.cancergencyto.2009.11.008

TY - JOUR

T1 - Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

AU - Bang, Soo Mee

AU - Seo, Ji Weon

AU - Park, Kyung Un

AU - Kim, Seok Jin

AU - Kim, Kihyun

AU - Kim, Sun Hee

AU - Cho, Sung Ran

AU - Kim, Hugh C.

AU - Song, Jaewoo

AU - Kim, Jin Seok

AU - Kim, Kyung Hee

AU - Lee, Jae Hoon

AU - Lee, Je Jung

AU - Shin, Myung Geun

AU - Suh, Cheolwon

AU - Chi, Hyun Sook

AU - Oh, Do yeun

AU - Won, Jong Ho

AU - Kim, Hyo Jung

AU - Yoon, Sung Soo

AU - Lee, Dong Soon

N1 - Funding Information: This work was supported in part by the National R&D Program for Cancer Control, Ministry of Health, Welfare and Family Affairs, Republic of Korea ( 0720440 ); Seoul National University Hospital Clinical Research Institute ( 04-2008-024-0 ); and the Korea Science and Engineering Foundation (KOSEF) funded by the Ministry of Education, Science, and Technology, Korea ( M1064152000106N415200110 ).

PY - 2010/3

Y1 - 2010/3

N2 - To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

AB - To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.

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U2 - 10.1016/j.cancergencyto.2009.11.008

DO - 10.1016/j.cancergencyto.2009.11.008

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SN - 0165-4608

VL - 197

SP - 117

EP - 121

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

IS - 2

ER -

Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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