Molecular cloning and anti-fungal effect of endo-β-1,3-glucanase from Thermotoga maritima

Chang Bin Woo, Hae Na Kang, Soo Bok Lee

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8 Citations (Scopus)


A gene encoding an endo-β-1,3-glucanase from Thermotoga maritima MSB8 (TmβG) was cloned and expressed in Escherichia coli. The purified enzyme produced various β-1,3-glucooligosaccharides from soluble laminarin, and mainly β-1,3-glucooligosaccharides smaller than laminaritetrose from insoluble curdlan. The optimum pH and temperature of the enzyme were 5.0 and 80°C, respectively. TmβG inhibited the growth of Candida albicans, which indicates that the enzyme could potentially be used as an anti-fungal agent to control invasive infections.

Original languageEnglish
Pages (from-to)1243-1246
Number of pages4
JournalFood Science and Biotechnology
Issue number4
Publication statusPublished - 2014 Aug

Bibliographical note

Funding Information:
Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Education, Science and Technology (2012R1A1A2005524).

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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