Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Chung Kyu Ryu; Hyeh Jean Jeong; Sang Kook Lee; Hye Young Kang; Kyung Min Ko; Yang Jung Sun; Eun Ha Song; Yeon Hoe Hur; Chong Ock Lee

doi:10.1007/BF02975239

Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Chung Kyu Ryu, Hyeh Jean Jeong, Sang Kook Lee, Hye Young Kang, Kyung Min Ko, Yang Jung Sun, Eun Ha Song, Yeon Hoe Hur, Chong Ock Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.

Original language	English
Pages (from-to)	554-558
Number of pages	5
Journal	Archives of pharmacal research
Volume	23
Issue number	6
DOIs	https://doi.org/10.1007/BF02975239
Publication status	Published - 2000

Bibliographical note

Funding Information:
This study was supported by the Brain Korea 21 Project and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities.

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02975239

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title = "Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential",

abstract = "Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.",

author = "Ryu, {Chung Kyu} and Jeong, {Hyeh Jean} and Lee, {Sang Kook} and Kang, {Hye Young} and Ko, {Kyung Min} and Sun, {Yang Jung} and Song, {Eun Ha} and Hur, {Yeon Hoe} and Lee, {Chong Ock}",

note = "Funding Information: This study was supported by the Brain Korea 21 Project and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities.",

year = "2000",

doi = "10.1007/BF02975239",

language = "English",

volume = "23",

pages = "554--558",

journal = "Archives of pharmacal research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

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T1 - Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

AU - Ryu, Chung Kyu

AU - Jeong, Hyeh Jean

AU - Lee, Sang Kook

AU - Kang, Hye Young

AU - Ko, Kyung Min

AU - Sun, Yang Jung

AU - Song, Eun Ha

AU - Hur, Yeon Hoe

AU - Lee, Chong Ock

N1 - Funding Information: This study was supported by the Brain Korea 21 Project and the MOST through National R&D Program (97-N6-01-01-A-18) for Women's Universities.

PY - 2000

Y1 - 2000

N2 - Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.

AB - Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluated for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with the cytosolic fractions derived from cultured human lung cancer cells and their cytotoxicity in cultured several human solid cancer cell lines. The 4,7-dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tested compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cytotoxic agents, and comparable modulators of NQO1 activity. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles, NAD(P)H, Quinone oxidoreductase (NQO1), Cytotoxicity.

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VL - 23

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EP - 558

JO - Archives of pharmacal research

JF - Archives of pharmacal research

IS - 6

ER -

Modulation of NAD (P) H:Quinone Oxidoreductase (NQO1) Activity Mediated by 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles and their Cytotoxic Potential

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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