Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy

Tae Im Kim; Jhang Ho Pak; Ju Byung Chae; Eung Kweon Kim; Hungwon Tchah

doi:10.1097/01.ico.0000164830.79970.71

Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy

Tae Im Kim, Jhang Ho Pak, Ju Byung Chae, Eung Kweon Kim, Hungwon Tchah

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Purpose: To report 4 patients with Avellino corneal dystrophy (ACD) who were treated with 0.02% mitomycin C (MMC) during phototherapeutic keratectomy (PTK). Methods: ACD was confirmed by polymorphism of the exon region in the BIGH3 gene using polymerase chain reaction followed by DNA sequencing analysis. Three patients with recurrent ACD and 1 patient with primary ACD underwent PTK. Intraoperative 0.02% MMC was applied topically with a soaked microsponge. Results: There was no recurrence of ACD in the heterozygotes, but there were recurrences with best-corrected visual acuity of 20/30 in the 2 homozygotes. Conclusion: Intraoperative use of topical 0.02% MMC in conjunction with PTK may prevent or delay the recurrence of ACD for at least for 1 year.

Original language	English
Pages (from-to)	220-223
Number of pages	4
Journal	Cornea
Volume	25
Issue number	2
DOIs	https://doi.org/10.1097/01.ico.0000164830.79970.71
Publication status	Published - 2006 Feb

All Science Journal Classification (ASJC) codes

Ophthalmology

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10.1097/01.ico.0000164830.79970.71

Cite this

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title = "Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy",

abstract = "Purpose: To report 4 patients with Avellino corneal dystrophy (ACD) who were treated with 0.02% mitomycin C (MMC) during phototherapeutic keratectomy (PTK). Methods: ACD was confirmed by polymorphism of the exon region in the BIGH3 gene using polymerase chain reaction followed by DNA sequencing analysis. Three patients with recurrent ACD and 1 patient with primary ACD underwent PTK. Intraoperative 0.02% MMC was applied topically with a soaked microsponge. Results: There was no recurrence of ACD in the heterozygotes, but there were recurrences with best-corrected visual acuity of 20/30 in the 2 homozygotes. Conclusion: Intraoperative use of topical 0.02% MMC in conjunction with PTK may prevent or delay the recurrence of ACD for at least for 1 year.",

author = "Kim, {Tae Im} and Pak, {Jhang Ho} and Chae, {Ju Byung} and Kim, {Eung Kweon} and Hungwon Tchah",

year = "2006",

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doi = "10.1097/01.ico.0000164830.79970.71",

language = "English",

volume = "25",

pages = "220--223",

journal = "Cornea",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy

AU - Kim, Tae Im

AU - Pak, Jhang Ho

AU - Chae, Ju Byung

AU - Kim, Eung Kweon

AU - Tchah, Hungwon

PY - 2006/2

Y1 - 2006/2

N2 - Purpose: To report 4 patients with Avellino corneal dystrophy (ACD) who were treated with 0.02% mitomycin C (MMC) during phototherapeutic keratectomy (PTK). Methods: ACD was confirmed by polymorphism of the exon region in the BIGH3 gene using polymerase chain reaction followed by DNA sequencing analysis. Three patients with recurrent ACD and 1 patient with primary ACD underwent PTK. Intraoperative 0.02% MMC was applied topically with a soaked microsponge. Results: There was no recurrence of ACD in the heterozygotes, but there were recurrences with best-corrected visual acuity of 20/30 in the 2 homozygotes. Conclusion: Intraoperative use of topical 0.02% MMC in conjunction with PTK may prevent or delay the recurrence of ACD for at least for 1 year.

AB - Purpose: To report 4 patients with Avellino corneal dystrophy (ACD) who were treated with 0.02% mitomycin C (MMC) during phototherapeutic keratectomy (PTK). Methods: ACD was confirmed by polymorphism of the exon region in the BIGH3 gene using polymerase chain reaction followed by DNA sequencing analysis. Three patients with recurrent ACD and 1 patient with primary ACD underwent PTK. Intraoperative 0.02% MMC was applied topically with a soaked microsponge. Results: There was no recurrence of ACD in the heterozygotes, but there were recurrences with best-corrected visual acuity of 20/30 in the 2 homozygotes. Conclusion: Intraoperative use of topical 0.02% MMC in conjunction with PTK may prevent or delay the recurrence of ACD for at least for 1 year.

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JO - Cornea

JF - Cornea

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ER -

Mitomycin C inhibits recurrent avellino dystrophy after phototherapeutic keratectomy

Abstract

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