Minimal energy requirement for external cardioversion and catheter ablation for long-standing persistent atrial fibrillation

In Soo Kim; Tae Hoon Kim; Pil Sung Yang; Jae Sun Uhm; Boyoung Joung; Moon Hyoung Lee; Hui Nam Pak

doi:10.1016/j.jjcc.2016.02.014

Minimal energy requirement for external cardioversion and catheter ablation for long-standing persistent atrial fibrillation

In Soo Kim, Tae Hoon Kim, Pil Sung Yang, Jae Sun Uhm, Boyoung Joung, Moon Hyoung Lee, Hui Nam Pak

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background The minimal energy requirement (E_min) for electrical cardioversion (ECV) reflects the atrial substrate in patients with long-standing persistent atrial fibrillation (L-PeAF), but the relationship between E_minECV and radiofrequency catheter ablation (RFCA) has not yet been studied. We hypothesize that E_minECV before ablation (E_minECVpre) predicts clinical outcome of RFCA, and that catheter ablation reduces E_minECVpost. Methods We included 172 patients with L-PeAF who underwent RFCA (79.7% males, 57.5 ± 10.0 years) due to AF recurrence after ECV with an anti-arrhythmic drug (AAD). ECV began with 70 J (patch electrode on anterior–posterior position) and was serially increased to 100, 150, 200, and 250 J until sinus rhythm was achieved, at an average 5.0 ± 5.6 months before RFCA. After RFCA, ECV was repeated (ECVpost) in 42 patients with recurrent AF that was not controlled by AAD. Results (1) During 34.8 ± 20.0 months of follow-up after RFCA, 103 patients (59.9%) showed clinical recurrence of AF after RFCA. E_minECVpre was significantly higher in patients with recurrent AF (129.0 ± 58.6 J) than those who remained in sinus rhythm (94.2 ± 39.4 J, p < 0.001). (2) E_minECVpre ≥150 J (HR = 3.31, 95% CI 2.18–5.03, p < 0.001) and left atrial volume index (HR = 1.02, 95% CI 1.00–1.04, p = 0.021) were significantly associated with post-RFCA recurrence. (3) Shorter post-RFCA recurrence timing was also independently related to E_minECVpre (β = −0.147, 95% CI −0.20 to −0.09, p < 0.001). (4) Among 103 patients with recurrent AF after RFCA, 42 AAD-resistant AF patients underwent ECVpost. E_minECVpost (100.9 ± 50.8 J) was significantly lower than E_minECVpre (130.0 ± 66.1 J, p = 0.006). Conclusions Higher E_minECVpre was independently associated with clinical recurrence and earlier recurrence timing of AF after catheter ablation among patients with AAD-resistant L-PeAF. Catheter ablation for L-PeAF significantly reduces E_minECV.

Original language	English
Pages (from-to)	162-168
Number of pages	7
Journal	Journal of Cardiology
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/j.jjcc.2016.02.014
Publication status	Published - 2017 Jan 1

Bibliographical note

Funding Information:
This work was supported by a grant ( A085136 ) from the Korea Health 21 R&D Project, Ministry of Health and Welfare and a grant ( 7-2013-0362 ) from the Basic Science Research Program of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT and Future Planning (MSIP) .

Publisher Copyright:
© 2016 Japanese College of Cardiology

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.jjcc.2016.02.014

Cite this

@article{94a13684fcef421a92839d1518c03757,

title = "Minimal energy requirement for external cardioversion and catheter ablation for long-standing persistent atrial fibrillation",

abstract = "Background The minimal energy requirement (Emin) for electrical cardioversion (ECV) reflects the atrial substrate in patients with long-standing persistent atrial fibrillation (L-PeAF), but the relationship between EminECV and radiofrequency catheter ablation (RFCA) has not yet been studied. We hypothesize that EminECV before ablation (EminECVpre) predicts clinical outcome of RFCA, and that catheter ablation reduces EminECVpost. Methods We included 172 patients with L-PeAF who underwent RFCA (79.7% males, 57.5 ± 10.0 years) due to AF recurrence after ECV with an anti-arrhythmic drug (AAD). ECV began with 70 J (patch electrode on anterior–posterior position) and was serially increased to 100, 150, 200, and 250 J until sinus rhythm was achieved, at an average 5.0 ± 5.6 months before RFCA. After RFCA, ECV was repeated (ECVpost) in 42 patients with recurrent AF that was not controlled by AAD. Results (1) During 34.8 ± 20.0 months of follow-up after RFCA, 103 patients (59.9%) showed clinical recurrence of AF after RFCA. EminECVpre was significantly higher in patients with recurrent AF (129.0 ± 58.6 J) than those who remained in sinus rhythm (94.2 ± 39.4 J, p < 0.001). (2) EminECVpre ≥150 J (HR = 3.31, 95% CI 2.18–5.03, p < 0.001) and left atrial volume index (HR = 1.02, 95% CI 1.00–1.04, p = 0.021) were significantly associated with post-RFCA recurrence. (3) Shorter post-RFCA recurrence timing was also independently related to EminECVpre (β = −0.147, 95% CI −0.20 to −0.09, p < 0.001). (4) Among 103 patients with recurrent AF after RFCA, 42 AAD-resistant AF patients underwent ECVpost. EminECVpost (100.9 ± 50.8 J) was significantly lower than EminECVpre (130.0 ± 66.1 J, p = 0.006). Conclusions Higher EminECVpre was independently associated with clinical recurrence and earlier recurrence timing of AF after catheter ablation among patients with AAD-resistant L-PeAF. Catheter ablation for L-PeAF significantly reduces EminECV.",

author = "Kim, {In Soo} and Kim, {Tae Hoon} and Yang, {Pil Sung} and Uhm, {Jae Sun} and Boyoung Joung and Lee, {Moon Hyoung} and Pak, {Hui Nam}",

note = "Funding Information: This work was supported by a grant ( A085136 ) from the Korea Health 21 R&D Project, Ministry of Health and Welfare and a grant ( 7-2013-0362 ) from the Basic Science Research Program of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT and Future Planning (MSIP) . Publisher Copyright: {\textcopyright} 2016 Japanese College of Cardiology",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.jjcc.2016.02.014",

language = "English",

volume = "69",

pages = "162--168",

journal = "Journal of Cardiology",

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TY - JOUR

T1 - Minimal energy requirement for external cardioversion and catheter ablation for long-standing persistent atrial fibrillation

AU - Kim, In Soo

AU - Kim, Tae Hoon

AU - Yang, Pil Sung

AU - Uhm, Jae Sun

AU - Joung, Boyoung

AU - Lee, Moon Hyoung

AU - Pak, Hui Nam

N1 - Funding Information: This work was supported by a grant ( A085136 ) from the Korea Health 21 R&D Project, Ministry of Health and Welfare and a grant ( 7-2013-0362 ) from the Basic Science Research Program of the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT and Future Planning (MSIP) . Publisher Copyright: © 2016 Japanese College of Cardiology

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background The minimal energy requirement (Emin) for electrical cardioversion (ECV) reflects the atrial substrate in patients with long-standing persistent atrial fibrillation (L-PeAF), but the relationship between EminECV and radiofrequency catheter ablation (RFCA) has not yet been studied. We hypothesize that EminECV before ablation (EminECVpre) predicts clinical outcome of RFCA, and that catheter ablation reduces EminECVpost. Methods We included 172 patients with L-PeAF who underwent RFCA (79.7% males, 57.5 ± 10.0 years) due to AF recurrence after ECV with an anti-arrhythmic drug (AAD). ECV began with 70 J (patch electrode on anterior–posterior position) and was serially increased to 100, 150, 200, and 250 J until sinus rhythm was achieved, at an average 5.0 ± 5.6 months before RFCA. After RFCA, ECV was repeated (ECVpost) in 42 patients with recurrent AF that was not controlled by AAD. Results (1) During 34.8 ± 20.0 months of follow-up after RFCA, 103 patients (59.9%) showed clinical recurrence of AF after RFCA. EminECVpre was significantly higher in patients with recurrent AF (129.0 ± 58.6 J) than those who remained in sinus rhythm (94.2 ± 39.4 J, p < 0.001). (2) EminECVpre ≥150 J (HR = 3.31, 95% CI 2.18–5.03, p < 0.001) and left atrial volume index (HR = 1.02, 95% CI 1.00–1.04, p = 0.021) were significantly associated with post-RFCA recurrence. (3) Shorter post-RFCA recurrence timing was also independently related to EminECVpre (β = −0.147, 95% CI −0.20 to −0.09, p < 0.001). (4) Among 103 patients with recurrent AF after RFCA, 42 AAD-resistant AF patients underwent ECVpost. EminECVpost (100.9 ± 50.8 J) was significantly lower than EminECVpre (130.0 ± 66.1 J, p = 0.006). Conclusions Higher EminECVpre was independently associated with clinical recurrence and earlier recurrence timing of AF after catheter ablation among patients with AAD-resistant L-PeAF. Catheter ablation for L-PeAF significantly reduces EminECV.

AB - Background The minimal energy requirement (Emin) for electrical cardioversion (ECV) reflects the atrial substrate in patients with long-standing persistent atrial fibrillation (L-PeAF), but the relationship between EminECV and radiofrequency catheter ablation (RFCA) has not yet been studied. We hypothesize that EminECV before ablation (EminECVpre) predicts clinical outcome of RFCA, and that catheter ablation reduces EminECVpost. Methods We included 172 patients with L-PeAF who underwent RFCA (79.7% males, 57.5 ± 10.0 years) due to AF recurrence after ECV with an anti-arrhythmic drug (AAD). ECV began with 70 J (patch electrode on anterior–posterior position) and was serially increased to 100, 150, 200, and 250 J until sinus rhythm was achieved, at an average 5.0 ± 5.6 months before RFCA. After RFCA, ECV was repeated (ECVpost) in 42 patients with recurrent AF that was not controlled by AAD. Results (1) During 34.8 ± 20.0 months of follow-up after RFCA, 103 patients (59.9%) showed clinical recurrence of AF after RFCA. EminECVpre was significantly higher in patients with recurrent AF (129.0 ± 58.6 J) than those who remained in sinus rhythm (94.2 ± 39.4 J, p < 0.001). (2) EminECVpre ≥150 J (HR = 3.31, 95% CI 2.18–5.03, p < 0.001) and left atrial volume index (HR = 1.02, 95% CI 1.00–1.04, p = 0.021) were significantly associated with post-RFCA recurrence. (3) Shorter post-RFCA recurrence timing was also independently related to EminECVpre (β = −0.147, 95% CI −0.20 to −0.09, p < 0.001). (4) Among 103 patients with recurrent AF after RFCA, 42 AAD-resistant AF patients underwent ECVpost. EminECVpost (100.9 ± 50.8 J) was significantly lower than EminECVpre (130.0 ± 66.1 J, p = 0.006). Conclusions Higher EminECVpre was independently associated with clinical recurrence and earlier recurrence timing of AF after catheter ablation among patients with AAD-resistant L-PeAF. Catheter ablation for L-PeAF significantly reduces EminECV.

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DO - 10.1016/j.jjcc.2016.02.014

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SN - 0914-5087

VL - 69

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JO - Journal of Cardiology

JF - Journal of Cardiology

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ER -

Minimal energy requirement for external cardioversion and catheter ablation for long-standing persistent atrial fibrillation

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