Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

Dinneswara Reddy Guda; Hyeon Mo Cho; Myong Euy Lee

doi:10.1039/c3ra00159h

Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

Dinneswara Reddy Guda, Hyeon Mo Cho, Myong Euy Lee

University College

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71-87%).

Original language	English
Pages (from-to)	6813-6816
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	19
DOIs	https://doi.org/10.1039/c3ra00159h
Publication status	Published - 2013 May 21

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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10.1039/c3ra00159h

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abstract = "A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71-87%).",

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AU - Guda, Dinneswara Reddy

AU - Cho, Hyeon Mo

AU - Lee, Myong Euy

PY - 2013/5/21

Y1 - 2013/5/21

N2 - A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71-87%).

AB - A novel and efficient one-pot method has been developed for the synthesis of 2-amino-1,3,4-thiadiazoles using various carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS). In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodehydration of thiosemicarbazides under acidic conditions gave 2-amino-1,3,4-thiadiazoles in high yields (71-87%).

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ER -

Mild and convenient one-pot synthesis of 2-amino-1,3,4-thiadiazoles using trimethylsilyl isothiocyanate (TMSNCS)

Abstract

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