Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)

Dinneswara Reddy Guda; Hyeon Mo Cho; Myong Euy Lee

doi:10.1039/c3ra41044g

Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)

Dinneswara Reddy Guda, Hyeon Mo Cho, Myong Euy Lee

University College

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I₂/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94%).

Original language	English
Pages (from-to)	7684-7687
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	21
DOIs	https://doi.org/10.1039/c3ra41044g
Publication status	Published - 2013 Jun 7

All Science Journal Classification (ASJC) codes

Chemistry(all)
Chemical Engineering(all)

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10.1039/c3ra41044g

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abstract = "A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94%).",

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AU - Guda, Dinneswara Reddy

AU - Cho, Hyeon Mo

AU - Lee, Myong Euy

PY - 2013/6/7

Y1 - 2013/6/7

N2 - A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94%).

AB - A mild, convenient, and efficient one-pot synthesis of amino-1,3,4- oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79-94%).

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JF - RSC Advances

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ER -

Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)

Abstract

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