Microscopic analysis of molar-incisor malformation

Hyo Seol Lee, Soo Hyun Kim, Seong Oh Kim, Byung Jai Choi, Sung Won Cho, Wonse Park, Je Seon Song

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Objective Molar-incisor malformation (MIM) is a newly discovered type of dental anomaly that involves a characteristic root malformation of the permanent first molars. The aim of this study was to reveal the microstructure of MIM teeth in order to determine their origin. Study Design Four MIM teeth were extracted from a 9-year-old girl due to severe mobility. The detailed microstructure of the teeth was determined by examinations with micro-computed tomography (micro-CT), hematoxylin and eosin (H&E) staining, immunohistochemical staining, and scanning electron microscopy to reveal the detailed microstructure. Results Micro-CT and H&E staining revealed the pulpal floor comprising three layers: upper, middle, and lower. Amorphous hard tissues and hyperactive cells were observed in the middle layer of the pulpal floor, and the cells stained positively for dentin sialoprotein and osteocalcin, but not for collagen XII. Conclusion The results of the present study imply that MIM-affected molars probably result from inappropriate differentiation of the apical pulp and dental follicle.

Original languageEnglish
Pages (from-to)544-552
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number5
Publication statusPublished - 2015 May 1

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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