Micronization of cilostazol using supercritical antisolvent (SAS) process: Effect of process parameters

Min Soo Kim, Sibeum Lee, Jeong Sook Park, Jong Soo Woo, Sung Joo Hwang

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97 Citations (Scopus)


The aim of this study was to improve dissolution rate of poorly water-soluble drug, cilostazol, using supercritical antisolvent (SAS) process. The effect of process variables, such as pressure, temperature, drug concentration, type of solvents, feed rate ratio of CO2/drug solution, on drug particle formation during SAS process was investigated. Particles with mean particle size ranging between 0.90 and 4.52 μm were obtained by varying process parameters such as precipitation vessel pressure and temperature, drug solution concentration, solvent type, feed rate ratio of CO2/drug solution. In particular, mean particle size and distribution were markedly influenced by drug solution concentration during SAS process. Moreover, the drug did not change its crystal form and the operating parameters might control the 'crystal texture' due to the change in crystallinity and preferred orientation during SAS process, as confirmed by differential scanning calorimetry and powder X-ray diffraction study. In addition, the dissolution rate of drug precipitated using SAS process was highly increased in comparison with unprocessed drug. Therefore, it is concluded that the dissolution rate of drug is significantly increased by micronization of cilostazol, leading to the reduction in particle size and increased specific surface area after SAS process.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalPowder Technology
Issue number2
Publication statusPublished - 2007 Aug 15

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology (No. M10300000301-06J0000-30110).

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)


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