@inproceedings{d23c213843ec434a95d1de7304aabc20,
title = "Microfluidic detection of circulating tumor cells (CTC) using side filtration-based capture",
abstract = "Highly sensitive detection of CTCs is difficult because they are extremely rare (i.e. 1∼5 CTC/ 109) in blood. Recently various devices were developed implementing a method of either affinity-based or size-based separation. There are some drawbacks of each method. Antibody-based capturing has low sensitivity if CTCs express less target surface antigen and the size of CTCs overlaps with that of normal blood cells. Hence we utilized a filter on the side of the channel for introducing a deformability in separation principle. The capturing result of this method demonstrated a higher capture rate (95%) and purity (99%) than conventional size-based filtration because easily-deformed CTCs stuck to the holes more tightly than normal blood cells.",
author = "Lee, {S. W.} and Kang, {J. Y.} and Jung, {H. I.} and Hyun, {K. A.}",
year = "2013",
language = "English",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "365--367",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}